Antiviral drug: Difference between revisions

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An '''antiviral drug''', or '''antiviral agent''', is a compound that interfers with the [[viral replication cycle|replication cycle]] of [[virus|viruses]].  They can be divided into three non-exclusive categories: [[protease inhibitor]]s, [[anti-metabolite]]s and [[reverse transcriptase inhibitor]]s, based on the ways in which they disrupt viral replication cycles.  While antiviral drugs are intended for systemic use by ingestion or injection of the drug, [[virucide]]s are used exclusively on objects and surfaces and, when possible, topically.
An '''antiviral drug''', or '''antiviral agent''', is a compound that interfers with the [[viral replication cycle|replication cycle]] of [[virus|viruses]].  They can be divided into three non-exclusive categories: [[protease inhibitor]]s, [[anti-metabolite]]s and [[reverse transcriptase inhibitor]]s, based on the ways in which they disrupt viral replication cycles.  While antiviral drugs are intended for systemic use by ingestion or injection of the drug, [[virucide]]s are used exclusively on objects and surfaces and, when possible, topically.


[[Protease inhibitor]]s, as the name suggests, inhibit the function of [[protease]] [[enzymes]] created by viruses.  The [[DNA]] or [[RNA]] in viruses are coded to produce large polyproteins, which need to be cleaved into smaller functional proteins by viral proteases before infectious, mature virus particles can be formed.  For example, [[West Nile virus]] and [[Dengue|Dengue virus]] produce a single polyprotein that must be cleaved into ten separate proteins.   
[[Protease inhibitor]]s, as the name suggests, inhibit the function of [[protease]] [[enzymes]] created by viruses.  The [[DNA]] or [[RNA]] in viruses are coded to produce large polyproteins, which need to be cleaved into smaller functional proteins by viral proteases before infectious, mature virus particles can be formed.  For example, [[West Nile virus]] and the [[Dengue fever]] virus produce a single polyprotein that must be cleaved into ten separate proteins.   


[[Anti-metabolite]]s, which are often nucleoside analogs that disrupt the replication or translation of viral [[DNA]] or [[RNA]] upon their incorporation or [[reverse transcriptase inhibitors]] (RTIs). Some drugs fit 2 or 3 of these categories.  More information about these drugs can be found in their respective article pages.
[[Anti-metabolite]]s are chemicals that mimic natural biochemical building blocks, and most often are analogs of the nucleotides used to make DNA and RNA.  Anti-metabolites act as DNA or RNA chain terminators during the replication or translation of viral DNA or RNA.  Often, the drugs are missing one of the necessary linkage groups, such as a 3'- or 5'-hydroxyl group in the sugar, sothat the drug gets incorporated into new viral RNA or DNA, but the next nucleotide base cannot be added because a linkage group is missing. Anti-metabolites also bind competitively with genuine metabolites in the active sites of the [[polyerases]] that create viral nucleic acids, and thus also slow down production of viral nucleic acids by clogging up the polymerases.
 
[[reverse transcriptase inhibitors]] (RTIs)  
 
 
 
  More information about these drugs can be found in their respective article pages.


== List of protease inhibitors ==
== List of protease inhibitors ==

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An antiviral drug, or antiviral agent, is a compound that interfers with the replication cycle of viruses. They can be divided into three non-exclusive categories: protease inhibitors, anti-metabolites and reverse transcriptase inhibitors, based on the ways in which they disrupt viral replication cycles. While antiviral drugs are intended for systemic use by ingestion or injection of the drug, virucides are used exclusively on objects and surfaces and, when possible, topically.

Protease inhibitors, as the name suggests, inhibit the function of protease enzymes created by viruses. The DNA or RNA in viruses are coded to produce large polyproteins, which need to be cleaved into smaller functional proteins by viral proteases before infectious, mature virus particles can be formed. For example, West Nile virus and the Dengue fever virus produce a single polyprotein that must be cleaved into ten separate proteins.

Anti-metabolites are chemicals that mimic natural biochemical building blocks, and most often are analogs of the nucleotides used to make DNA and RNA. Anti-metabolites act as DNA or RNA chain terminators during the replication or translation of viral DNA or RNA. Often, the drugs are missing one of the necessary linkage groups, such as a 3'- or 5'-hydroxyl group in the sugar, sothat the drug gets incorporated into new viral RNA or DNA, but the next nucleotide base cannot be added because a linkage group is missing. Anti-metabolites also bind competitively with genuine metabolites in the active sites of the polyerases that create viral nucleic acids, and thus also slow down production of viral nucleic acids by clogging up the polymerases.

reverse transcriptase inhibitors (RTIs) 


More information about these drugs can be found in their respective article pages.

List of protease inhibitors


antimetabolites and RT inhibitors

  • Abacavir - a powerful nucleoside analog reverse transcriptase inhibitor used to treat HIV and AIDS.
  • Adefovir Dipivoxil - nucleotide analog reverse transcriptase inhibitor (ntRTI) hepatitis B treatment.
  • Delavirdine - A non-nucleoside reverse transcriptase (RT) inhibitor active against HIV-1.
  • Didanosine - a dideoxynucleoside prevents phosphodiester bonds; it is an inhibitor of HIV replication.
  • Entecavir - a guanosine analog for treatment of hepatitis B.
  • Efavirenz - a non-nucleoside reverse transcriptase inhibitor (NNRTI)used to treat HIV.
  • Foscarnet - inorganic pyrophosphate analog treats CMV retinitis, herpesviruses, and HIV.
  • Idoxuridine - a deoxyuridine analog that inhibits viral DNA synthesis.
  • Lamivudine - An RT inhibitor, zalcitabine analog used to treat HIV disease
  • Nevirapine - a non-nucleoside reverse transcriptase inhibitor used to treate HIV/AIDS
  • Oseltamivir (Tamaflu) - inhibits neuraminidase in the treatment of influenza infections.
  • Ribavirin - a nucleoside antimetabolite used against both RNA and DNA viruses.
  • Rimantadine - a cyclic amine derivate of adamantane, inhibits replication of influenza A, but not B.
  • Stavudine - A dideoxynucleoside analog, inhibits reverse transcriptase in HIV treatment.
  • Tenofovir - a nucleoside analog, reverse transcriptase inhibitor (nRTI),
  • Vidarabine - purine nucleoside analogue for the treatment of chickenpox (varicella) and herpes viruses
  • Zalcitabine - a dideoxynucleoside, prevents phosphodiester bonds, a potent inhibitor of HIV replication.
  • Zanamivir - a guanido-neuraminic acid used to inhibit neuraminidase, inhibits influenza.
  • Zidovudine - A dideoxynucleoside, prevents phosphodiester bonds, a potent inhibitor of HIV replication.

External Links

Drug Bank at http://www.drugbank.ca/cat_browse.htm#subC10

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