Ritonavir: Difference between revisions
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'''Ritonavir''', sold under the brand names '''Norvir®''' and '''Norvir Sec®''', and as a mixture with [[Lopinavir]] called '''Kaletra®''', is a [[protease inhibitor]] used to treat [[HIV]]/[[AIDS]] by disrupting the reproductive cycle of the [[virus]]. Ritonavir binds to and inhibits the HIV-1 viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles. Protease inhibitors like ritonavir are almost always used in combination with at least two other anti-HIV drugs. | '''Ritonavir''', sold under the brand names '''Norvir®''' and '''Norvir Sec®''', and as a mixture with [[Lopinavir]] called '''Kaletra®''', is a [[protease inhibitor]] used to treat [[HIV]]/[[AIDS]] by disrupting the reproductive cycle of the [[virus]]. Ritonavir binds to and inhibits the HIV-1 viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles. Protease inhibitors like ritonavir are almost always used in combination with at least two other anti-HIV drugs. | ||
== Chemistry == | |||
Its chemical name is 1,3-thiazol-5-ylmethyl N-[(2S,3S,5S)-3-hydroxy-5-[[(2S)-3-methyl-2-[[methyl-[(2-propan- | Its chemical name is 1,3-thiazol-5-ylmethyl N-[(2S,3S,5S)-3-hydroxy-5-[[(2S)-3-methyl-2-[[methyl-[(2-propan- | ||
2-yl-1,3-thiazol-4-yl)methyl]carbamoyl]amino]butanoyl]amino]-1,6-di(phenyl)hexan- | 2-yl-1,3-thiazol-4-yl)methyl]carbamoyl]amino]butanoyl]amino]-1,6-di(phenyl)hexan- | ||
Revision as of 09:38, 22 March 2008
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| ritonavir | |||||||
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| Uses: | HIV | ||||||
| Properties: | protease inhibitor | ||||||
| Hazards: | see drug interactions | ||||||
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Ritonavir, sold under the brand names Norvir® and Norvir Sec®, and as a mixture with Lopinavir called Kaletra®, is a protease inhibitor used to treat HIV/AIDS by disrupting the reproductive cycle of the virus. Ritonavir binds to and inhibits the HIV-1 viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles. Protease inhibitors like ritonavir are almost always used in combination with at least two other anti-HIV drugs.
Chemistry
Its chemical name is 1,3-thiazol-5-ylmethyl N-[(2S,3S,5S)-3-hydroxy-5-[[(2S)-3-methyl-2-[[methyl-[(2-propan- 2-yl-1,3-thiazol-4-yl)methyl]carbamoyl]amino]butanoyl]amino]-1,6-di(phenyl)hexan- 2-yl]carbamate and its chemical formula is C37H48N6O5S2.
External Links
- Ritonavir - FDA approved drug information (drug label) from DailyMed (U.S. National Library of Medicine).
- Template:MedMaster
- Template:DrugBank