Chlordiazepoxide: Difference between revisions
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In [[medicine]], '''chlordiazepoxide ''' is an "anxiolytic [[benzodiazepine]] derivative with [[anticonvulsant]], [[sedative]], and amnesic properties. It has also been used in the symptomatic | In [[medicine]], '''chlordiazepoxide ''' is an "anxiolytic [[benzodiazepine]] derivative with [[anticonvulsant]], [[sedative]], and amnesic properties. It has also been used in the symptomatic | ||
treatment of alcohol withdrawal."<ref>{{MeSH}}</ref> | treatment of alcohol withdrawal."<ref>{{MeSH}}</ref> It was the first benzodiazepine (BZD) in wide clinical use, marketed as '''Librium'''. | ||
==Pharmacology== | ==Pharmacology== | ||
Revision as of 11:45, 13 June 2010
In medicine, chlordiazepoxide is an "anxiolytic benzodiazepine derivative with anticonvulsant, sedative, and amnesic properties. It has also been used in the symptomatic treatment of alcohol withdrawal."[1] It was the first benzodiazepine (BZD) in wide clinical use, marketed as Librium.
Pharmacology
Administration
Distribution
Metabolism
Excretion
The half-life of chlordiazepoxide's metabolites desmethylchlordiazepoxide and demoxepam may be prolonged to 346 hours and 150 hours, respectively, in liver disease.[2]
Toxicity
It often has more anticholingergic effects that other benzodiazepines, but this is sometimes exploited, or even supplemented with additional anticholinergic ingredients, for anxiety coupled with gastrointestinal discomfort.
External links
The most up-to-date information about Chlordiazepoxide and other drugs can be found at the following sites.
- Chlordiazepoxide - FDA approved drug information (drug label) from DailyMed (U.S. National Library of Medicine).
- Chlordiazepoxide - Drug information for consumers from MedlinePlus (U.S. National Library of Medicine).
- Chlordiazepoxide - Detailed information from DrugBank.
References
- ↑ Anonymous (2024), Chlordiazepoxide (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ Barton K, Auld PW, Scott MG, Nicholls DP (1989 Jan-Feb). "Chlordiazepoxide metabolite accumulation in liver disease.". Med Toxicol Adverse Drug Exp 4 (1): 73-6. PMID 2710011.