Nitrile: Difference between revisions
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*Nitriles are reduced to imines, then hydrolyzed to the aldehyde in the '''Stephens aldehyde synthesis'''. | *Nitriles are reduced to imines, then hydrolyzed to the aldehyde in the '''Stephens aldehyde synthesis'''. | ||
*Beta-ketoesters are formed from alpha-bromoesters and nitriles in the '''Blaise reaction'''. | *Beta-ketoesters are formed from alpha-bromoesters and nitriles in the '''Blaise reaction'''. | ||
*Nitriles are hydrolysed to amides by acid | |||
Revision as of 16:51, 27 October 2010
A nitrile is an organic compound containing a carbon triple bonded to nitrogen.
Synthesis
- The Sandmeyer reaction employing cuprous cyanide can be used to form nitriles from diazonium compounds.
- Aryl nitriles may be formed from aryl halides in the Rosenmund-von Braun reaction.
Reactivity
- Nitriles are reduced to imines, then hydrolyzed to the aldehyde in the Stephens aldehyde synthesis.
- Beta-ketoesters are formed from alpha-bromoesters and nitriles in the Blaise reaction.
- Nitriles are hydrolysed to amides by acid