Microscopic polyangiitis: Difference between revisions
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'''Microscopic polyangiitis''' is a [[vasculitis]].<ref name="pmid16876669">{{cite journal| author=Bosch X, Guilabert A, Font J| title=Antineutrophil cytoplasmic antibodies. | journal=Lancet | year= 2006 | volume= 368 | issue= 9533 | pages= 404-18 | pmid=16876669 | '''Microscopic polyangiitis''' is a [[vasculitis]].<ref name="pmid16876669">{{cite journal| author=Bosch X, Guilabert A, Font J| title=Antineutrophil cytoplasmic antibodies. | journal=Lancet | year= 2006 | volume= 368 | issue= 9533 | pages= 404-18 | pmid=16876669 | ||
| url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=16876669 | doi=10.1016/S0140-6736(06)69114-9 }} <!--Formatted by http://sumsearch.uthscsa.edu/cite/--></ref> | | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=16876669 | doi=10.1016/S0140-6736(06)69114-9 }} <!--Formatted by http://sumsearch.uthscsa.edu/cite/--></ref> It preferentially attacks the kidneys and the lungs. | ||
== | ==Manifestations== | ||
Common manifestations are: | Common manifestations are: | ||
* About 90% of patients have [[glomerulonephritis]] similar to [[Wegener's granulomatosis]]<ref name="pmid16876669"/> | * About 90% of patients have [[glomerulonephritis]] similar to [[Wegener's granulomatosis]]<ref name="pmid16876669"/> | ||
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* About half may have peripheral neuropathy.<ref name="pmid17299018">{{cite journal| author=Cattaneo L, Chierici E, Pavone L, Grasselli C, Manganelli P, Buzio C et al.| title=Peripheral neuropathy in Wegener's granulomatosis, Churg-Strauss syndrome and microscopic polyangiitis. | journal=J Neurol Neurosurg Psychiatry | year= 2007 | volume= 78 | issue= 10 | pages= 1119-23 | pmid=17299018 | * About half may have peripheral neuropathy.<ref name="pmid17299018">{{cite journal| author=Cattaneo L, Chierici E, Pavone L, Grasselli C, Manganelli P, Buzio C et al.| title=Peripheral neuropathy in Wegener's granulomatosis, Churg-Strauss syndrome and microscopic polyangiitis. | journal=J Neurol Neurosurg Psychiatry | year= 2007 | volume= 78 | issue= 10 | pages= 1119-23 | pmid=17299018 | ||
| url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=17299018 | doi=10.1136/jnnp.2006.111013 }} <!--Formatted by http://sumsearch.uthscsa.edu/cite/--></ref> | | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=17299018 | doi=10.1136/jnnp.2006.111013 }} <!--Formatted by http://sumsearch.uthscsa.edu/cite/--></ref> | ||
==Diagnosis== | |||
===Laboratory=== | |||
[[Anti-neutrophil cytoplasmic antibodies]] (ANCA) are usually elevated. Characteristically, there are no [[immunoglobulin]] deposits. | |||
==References== | ==References== | ||
<references/> | <references/> | ||
Revision as of 12:36, 1 August 2010
Microscopic polyangiitis is a vasculitis.[1] It preferentially attacks the kidneys and the lungs.
Manifestations
Common manifestations are:
- About 90% of patients have glomerulonephritis similar to Wegener's granulomatosis[1]
- About half may have pulmonary hemorrhage[1]
- About half may have peripheral neuropathy.[2]
Diagnosis
Laboratory
Anti-neutrophil cytoplasmic antibodies (ANCA) are usually elevated. Characteristically, there are no immunoglobulin deposits.
References
- ↑ 1.0 1.1 1.2 Bosch X, Guilabert A, Font J (2006). "Antineutrophil cytoplasmic antibodies.". Lancet 368 (9533): 404-18. DOI:10.1016/S0140-6736(06)69114-9. PMID 16876669. Research Blogging.
- ↑ Cattaneo L, Chierici E, Pavone L, Grasselli C, Manganelli P, Buzio C et al. (2007). "Peripheral neuropathy in Wegener's granulomatosis, Churg-Strauss syndrome and microscopic polyangiitis.". J Neurol Neurosurg Psychiatry 78 (10): 1119-23. DOI:10.1136/jnnp.2006.111013. PMID 17299018. Research Blogging.