Malassezia pachydermatis: Difference between revisions

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==Description and Significance==
==Description and Significance==
Malassezia pachydermatis is a lipophilic organism (prefer lipid rich areas) whose uncontrolled growth may lead to pruritic (itching) dermatitis. <sup>1</sup>  It is one of the 10 species that make up the Malassezia genus.  It most commonly affects pets that have preexisting allergies that have not properly been treated or are predisposed to excess moisture in certain parts of the body such as the ear canal or nail bed. <sup>1</sup> 
'''Signs and Symptoms'''
Each case is unique but may exhibit varying degrees of the following symptoms: <sup>1, 2, 3</sup>
*Lesions between the affected pets skin folds and varying parts of the body.
*Bruised skin may be red (erythematous), hyperpigmented, scaly, greasy or dry.  The fur may also be stained brown due to saliva staining from excessive licking.
*Persistent and painful scratching and head shaking.
*The skin folds may also have plaques or discharge as a result of a seborrheic infection.
*A strong odor similar to that of rancid milk.
'''Treatment Methods'''
Treatment may vary depending on the doctor and the severity of the case but may include: <sup>1, 3</sup>
*Topical medications that are both antiseborrheic and antifungal that should be used several times a week.  They may include formulas that are salicylic acid, benzoyl peroxide, or ketoconazole based among other medications. 
*Systemic (oral) medications can be used in conjunction with topical therapies or for the most severe cases.  Medications such as ketoconazole, itraconazole, or fluconazole may be used. 
*Oral antibiotics are also helpful to treat secondary bacterial infection that may arise. 
In severe cases that do not respond quickly to treatment the infection may only be controlled when the underlying cause of Malassezia overgrowth is suppressed. <sup>3</sup>  It should also be noted that excessive use of corticosteroids may lead the Malassezia pachydermatis to develop a resistance to therapy and there will be an overgrowth of the yeast that may not be easily treated.


==Genome structure==
==Genome structure==

Revision as of 21:22, 21 April 2009

Description and Significance

Malassezia pachydermatis is a lipophilic organism (prefer lipid rich areas) whose uncontrolled growth may lead to pruritic (itching) dermatitis. 1 It is one of the 10 species that make up the Malassezia genus. It most commonly affects pets that have preexisting allergies that have not properly been treated or are predisposed to excess moisture in certain parts of the body such as the ear canal or nail bed. 1

Signs and Symptoms Each case is unique but may exhibit varying degrees of the following symptoms: 1, 2, 3

  • Lesions between the affected pets skin folds and varying parts of the body.
  • Bruised skin may be red (erythematous), hyperpigmented, scaly, greasy or dry. The fur may also be stained brown due to saliva staining from excessive licking.
  • Persistent and painful scratching and head shaking.
  • The skin folds may also have plaques or discharge as a result of a seborrheic infection.
  • A strong odor similar to that of rancid milk.

Treatment Methods Treatment may vary depending on the doctor and the severity of the case but may include: 1, 3

  • Topical medications that are both antiseborrheic and antifungal that should be used several times a week. They may include formulas that are salicylic acid, benzoyl peroxide, or ketoconazole based among other medications.
  • Systemic (oral) medications can be used in conjunction with topical therapies or for the most severe cases. Medications such as ketoconazole, itraconazole, or fluconazole may be used.
  • Oral antibiotics are also helpful to treat secondary bacterial infection that may arise.

In severe cases that do not respond quickly to treatment the infection may only be controlled when the underlying cause of Malassezia overgrowth is suppressed. 3 It should also be noted that excessive use of corticosteroids may lead the Malassezia pachydermatis to develop a resistance to therapy and there will be an overgrowth of the yeast that may not be easily treated.

Genome structure

Cell Structure and Metabolism

Ecology

Pathology

Application to Biotechnology

Current Research

References