B-Cell chronic lymphocytic leukemia: Difference between revisions

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In [[medicine]], '''B-Cell chronic lymphocytic leukemia''', also called '''chronic lymphocytic leukemia''' ('''CLL'''), is a "chronic [[leukemia]] characterized by abnormal B-lymphocytes and often generalized lymphadenopathy. In patients presenting predominately with blood and bone marrow involvement it is called chronic lymphocytic leukemia (CLL); in those predominately with enlarged lymph nodes it is called small lymphocytic lymphoma. These terms represent spectrums of the same disease."<ref>{{MeSH}}</ref><ref name="pmid16983131">{{cite journal |author=Shanafelt TD, Byrd JC, Call TG, Zent CS, Kay NE |title=Narrative review: initial management of newly diagnosed, early-stage chronic lymphocytic leukemia |journal=Ann. Intern. Med. |volume=145 |issue=6 |pages=435–47 |year=2006 |month=September |pmid=16983131 |doi= |url=http://www.annals.org/cgi/content/full/145/6/435 |issn=}}</ref><ref name="pmid15728813">{{cite journal |author=Chiorazzi N, Rai KR, Ferrarini M |title=Chronic lymphocytic leukemia |journal=N. Engl. J. Med. |volume=352 |issue=8 |pages=804–15 |year=2005 |month=February |pmid=15728813 |doi=10.1056/NEJMra041720 |url=http://content.nejm.org/cgi/content/full/352/8/804 |issn=}}</ref>
In [[medicine]], '''B-Cell chronic lymphocytic leukemia''', also called '''chronic lymphocytic leukemia''' ('''CLL'''), is a "chronic [[leukemia]] characterized by abnormal B-lymphocytes and often generalized lymphadenopathy. In patients presenting predominately with blood and bone marrow involvement it is called chronic lymphocytic leukemia (CLL); in those predominately with enlarged lymph nodes it is called small lymphocytic lymphoma. These terms represent spectrums of the same disease."<ref>{{MeSH}}</ref><ref name="pmid16983131">{{cite journal |author=Shanafelt TD, Byrd JC, Call TG, Zent CS, Kay NE |title=Narrative review: initial management of newly diagnosed, early-stage chronic lymphocytic leukemia |journal=Ann. Intern. Med. |volume=145 |issue=6 |pages=435–47 |year=2006 |month=September |pmid=16983131 |doi= |url=http://www.annals.org/cgi/content/full/145/6/435 |issn=}}</ref><ref name="pmid15728813">{{cite journal |author=Chiorazzi N, Rai KR, Ferrarini M |title=Chronic lymphocytic leukemia |journal=N. Engl. J. Med. |volume=352 |issue=8 |pages=804–15 |year=2005 |month=February |pmid=15728813 |doi=10.1056/NEJMra041720 |url=http://content.nejm.org/cgi/content/full/352/8/804 |issn=}}</ref>


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In medicine, B-Cell chronic lymphocytic leukemia, also called chronic lymphocytic leukemia (CLL), is a "chronic leukemia characterized by abnormal B-lymphocytes and often generalized lymphadenopathy. In patients presenting predominately with blood and bone marrow involvement it is called chronic lymphocytic leukemia (CLL); in those predominately with enlarged lymph nodes it is called small lymphocytic lymphoma. These terms represent spectrums of the same disease."[1][2][3]

Prognosis

5-Year Relative Survival Rates By Year Dx By Leukemia type All Ages, All Races, Both Sexes 1975-2000.

Staging information

B-Cell chronic lymphocytic leukemia staging information from the National Cancer Institute's Physician Data Query


Treatment

B-Cell chronic lymphocytic leukemia treatment information from the National Cancer Institute's Physician Data Query


As a primary antineoplastic agent, fludarabine may be more effective than chlorambucil.[4]


Treatment options for Stage I, II, III, and IV CLL[5]
Regimen Effectiveness Adverse effects
Combination:[6][7]
• Fludarabine
• Cyclophosphamide
• Rituximab		 Complete remission in 25% to 72% • Neutropenia
• 10% rate of infection during first year
• Rituximab induced fever (37%), chills (50%), hypotension (13%), nausea and vomiting

References

  1. ↑ Anonymous (2024), B-Cell chronic lymphocytic leukemia (English). Medical Subject Headings. U.S. National Library of Medicine.
  2. ↑ Shanafelt TD, Byrd JC, Call TG, Zent CS, Kay NE (September 2006). "Narrative review: initial management of newly diagnosed, early-stage chronic lymphocytic leukemia". Ann. Intern. Med. 145 (6): 435–47. PMID 16983131. [e]
  3. ↑ Chiorazzi N, Rai KR, Ferrarini M (February 2005). "Chronic lymphocytic leukemia". N. Engl. J. Med. 352 (8): 804–15. DOI:10.1056/NEJMra041720. PMID 15728813. Research Blogging.
  4. ↑ Rai KR, Peterson BL, Appelbaum FR, et al (December 2000). "Fludarabine compared with chlorambucil as primary therapy for chronic lymphocytic leukemia". N. Engl. J. Med. 343 (24): 1750–7. PMID 11114313. [e]
  5. ↑ Anonymous. Chronic Lymphocytic Leukemia Treatment -. National Cancer Institute. Retrieved on 2009-03-31.
  6. ↑ Wierda W, O'Brien S, Wen S, et al (June 2005). "Chemoimmunotherapy with fludarabine, cyclophosphamide, and rituximab for relapsed and refractory chronic lymphocytic leukemia". J. Clin. Oncol. 23 (18): 4070–8. DOI:10.1200/JCO.2005.12.516. PMID 15767647. Retrieved on 2009-03-31. Research Blogging.
  7. ↑ Tam CS, O'Brien S, Wierda W, et al (August 2008). "Long-term results of the fludarabine, cyclophosphamide, and rituximab regimen as initial therapy of chronic lymphocytic leukemia". Blood 112 (4): 975–80. DOI:10.1182/blood-2008-02-140582. PMID 18411418. Retrieved on 2009-03-31. Research Blogging.
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