Colchicine: Difference between revisions
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==Drug interactions== | ==Drug interactions== | ||
Colchicine is metabolized by the CYP3A4 [[isoenzyme]] of [[cytochrome P-450]]. | Colchicine is metabolized by the CYP3A4 [[isoenzyme]] of [[cytochrome P-450]] and may interact with other durgs with similar metabolism.<ref name="pmid18490798">{{cite journal |author=van der Velden W, Huussen J, Ter Laak H, de Sévaux R |title=Colchicine-induced neuromyopathy in a patient with chronic renal failure: the role of clarithromycin |journal=Neth J Med |volume=66 |issue=5 |pages=204–6 |year=2008 |month=May |pmid=18490798 |doi= |url=http://www.zuidencomm.nl/njm/getarticle.php?v=66&i=5&p=204 |issn=}}</ref> Colchicine my also down regulate CYP2C9.<ref name="pmid12815172">{{cite journal |author=Dvorak Z, Modriansky M, Pichard-Garcia L, ''et al'' |title=Colchicine down-regulates cytochrome P450 2B6, 2C8, 2C9, and 3A4 in human hepatocytes by affecting their glucocorticoid receptor-mediated regulation |journal=Mol. Pharmacol. |volume=64 |issue=1 |pages=160–9 |year=2003 |month=July |pmid=12815172 |doi=10.1124/mol.64.1.160 |url=http://molpharm.aspetjournals.org/cgi/pmidlookup?view=long&pmid=12815172 |issn=}}</ref> | ||
==References== | ==References== | ||
Revision as of 20:28, 25 January 2009
In pharmacology, colchicine is a "major alkaloid from Colchicum autumnale L. and found also in other Colchicum species. Its primary therapeutic use is in the treatment of gout, but it has been used also in the therapy of familial Mediterranean fever (period disease)."[1]
Dosage
Acute gout attack
Initially 1 to 1.2 milligrams, then one of the following until symptoms better or gastrointestinal drug toxicity (stomach pain, vomiting or diarrhea) occur:[2]
- 0.5 to 0.6 milligram every hour
- 1 to 1.2 milligrams every two hours. 0.5 mg every 2 hours has been used, but still causes consistent toxicity[3]
- 0.5 to 0.6 milligram every 2 to 3 hours
The maximum dose per attack is 4 to 8 milligrams total.
Prevention of gout
Clinical practice guidelines recommend 0.5 to 1.0 mg per day.[4]
Drug interactions
Colchicine is metabolized by the CYP3A4 isoenzyme of cytochrome P-450 and may interact with other durgs with similar metabolism.[5] Colchicine my also down regulate CYP2C9.[6]
References
- ↑ Anonymous (2024), Colchicine (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ Colchicine. In: DRUGDEX® System (Internet database). Greenwood Village, Colo: Thomson Healthcare. Updated periodically.
- ↑ Ahern MJ, Reid C, Gordon TP, McCredie M, Brooks PM, Jones M (June 1987). "Does colchicine work? The results of the first controlled study in acute gout". Aust N Z J Med 17 (3): 301–4. DOI:10.1111/j.1445-5994.1987.tb01232.x. PMID 3314832. Research Blogging. Summary at Bandolier
- ↑ Zhang W, Doherty M, Bardin T, et al (October 2006). "EULAR evidence based recommendations for gout. Part II: Management. Report of a task force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT)". Ann. Rheum. Dis. 65 (10): 1312–24. DOI:10.1136/ard.2006.055269. PMID 16707532. Research Blogging.
- ↑ van der Velden W, Huussen J, Ter Laak H, de Sévaux R (May 2008). "Colchicine-induced neuromyopathy in a patient with chronic renal failure: the role of clarithromycin". Neth J Med 66 (5): 204–6. PMID 18490798. [e]
- ↑ Dvorak Z, Modriansky M, Pichard-Garcia L, et al (July 2003). "Colchicine down-regulates cytochrome P450 2B6, 2C8, 2C9, and 3A4 in human hepatocytes by affecting their glucocorticoid receptor-mediated regulation". Mol. Pharmacol. 64 (1): 160–9. DOI:10.1124/mol.64.1.160. PMID 12815172. Research Blogging.
External references
The most up-to-date information about Colchicine and other drugs can be found at the following sites.
- Colchicine - FDA approved drug information (drug label) from DailyMed (U.S. National Library of Medicine).
- Colchicine - Drug information for consumers from MedlinePlus (U.S. National Library of Medicine).
- Colchicine - Detailed information from DrugBank.