Polymicrogyria: Difference between revisions
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'''Polymicrogyria''' (also known as ''cobblestone lissencephaly'') is a [[neurodevelopmental disorder]] with abnormal [[gyrification]] of the [[cerebral cortex]]: Instead of the few and large convolutions ([[gyrus|gyri]]), multiple small convolutions occur, in the result of which the [[brain surface]] appears [[pebble]]d. Further diagnostic criteria include [[white matter]] reduction, [[brain ventricle|ventricular]] enlargement, and [[hypoplasia]] of the [[brainstem]] and [[cerebellum]]<ref name=Pabuşçu2002>{{citation | '''Polymicrogyria''' (also known as ''cobblestone lissencephaly'') is a [[neurodevelopmental disorder]] with abnormal [[gyrification]] of the [[cerebral cortex]]: Instead of the few and large convolutions ([[gyrus|gyri]]) typical for normal [[brain development]], multiple small convolutions occur, in the result of which the [[brain surface]] appears [[pebble]]d. Further diagnostic criteria include [[white matter]] reduction, [[brain ventricle|ventricular]] enlargement, and [[hypoplasia]] of the [[brainstem]] and [[cerebellum]]<ref name=Pabuşçu2002>{{citation | ||
| last1 = Pabuşçu | first1 = Y. | | last1 = Pabuşçu | first1 = Y. | ||
| last2 = Bulakbaşý | first2 = N. | | last2 = Bulakbaşý | first2 = N. | ||
Revision as of 19:35, 25 December 2008
Polymicrogyria (also known as cobblestone lissencephaly) is a neurodevelopmental disorder with abnormal gyrification of the cerebral cortex: Instead of the few and large convolutions (gyri) typical for normal brain development, multiple small convolutions occur, in the result of which the brain surface appears pebbled. Further diagnostic criteria include white matter reduction, ventricular enlargement, and hypoplasia of the brainstem and cerebellum[1][2].
References
- ↑ Pabuşçu, Y.; N. Bulakbaşý & M. Kocaoğlu et al. (2002), "Walker–Warburg syndrome variant", Computerized Medical Imaging and Graphics 26 (6): 453–458, DOI:10.1016/S0895-6111(02)00026-5 [e]
- ↑ Jansen, A. & E. Andermann (2005), "Genetics of the polymicrogyria syndromes", Journal of Medical Genetics 42 (5): 369, DOI:10.1136/jmg.2004.023952 [e]