Methotrexate/Definition: Difference between revisions
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imported>David E. Volk (New page: <noinclude>{{Subpages}}</noinclude> Drug used to treat rheumatoid arthritis.) |
imported>Howard C. Berkowitz No edit summary |
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An inhibitor of [[tetrahydrofolate dehydrogenase]], which prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA. Wide range of applications, including the treatment of cancer; autoimmune diseases (where it is considered a [[disease-modifying antirheumatic drug]]) including [[asthma]], [[rheumatoid arthritis]]. | |||
Revision as of 06:45, 5 February 2009
An inhibitor of tetrahydrofolate dehydrogenase, which prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA. Wide range of applications, including the treatment of cancer; autoimmune diseases (where it is considered a disease-modifying antirheumatic drug) including asthma, rheumatoid arthritis.