Cefazolin: Difference between revisions

From Citizendium
Jump to navigation Jump to search
imported>David E. Volk
imported>David E. Volk
mNo edit summary
Line 17: Line 17:
'''Cefazolin''', also called '''cefazoline''', '''cephazolin''' or '''CEZ''', is a semisynthetic [[cephalosporin]] [[antibiotic]] sold under the brand name Ancef®.  It is primarily used to treat bacterial skin infections, but can be used to treat moderately severe bacterial infections involving the lungs, bones, joints, stomach, blood, heart valves or the urinary tract. It is effective against [[staphylococci]] and [[streptococci]] species of [[Gram-positive]] bacteria.
'''Cefazolin''', also called '''cefazoline''', '''cephazolin''' or '''CEZ''', is a semisynthetic [[cephalosporin]] [[antibiotic]] sold under the brand name Ancef®.  It is primarily used to treat bacterial skin infections, but can be used to treat moderately severe bacterial infections involving the lungs, bones, joints, stomach, blood, heart valves or the urinary tract. It is effective against [[staphylococci]] and [[streptococci]] species of [[Gram-positive]] bacteria.
It is given by IV ([[parenterally]]).
It is given by IV ([[parenterally]]).
== Mechanism of action ==
Like other cephalosporins and [[penicillin]]s, cefazolin binds to [[penicillin-binding protein]]s thus interfering with the final stage of bacterial cell wall synthesis, the peptidoglycan layer, and causing [[autolysis]] of the cells by [[autolysin]]s enzymes.
== Chemistry ==
Cefazolin has the IUPAC chemical name (7R)-3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-8-oxo-7-[[2-(tetrazol-1-yl)
acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, molecular formula  C<sub>14</sub>H<sub>14</sub>N<sub>8</sub>O<sub>4</sub>S<sub>3</sub> and molecular mass 454.5072 g/mol.  It is a cephalosporin and contains a [[beta-lactam]] moiety.
== External links ==
* {{CZMed}}

Revision as of 15:30, 5 April 2009

This article is a stub and thus not approved.
 Main Article
 Discussion
Related Articles  [?]
Bibliography  [?]
External Links  [?]
Citable Version  [?]
 
https://en.citizendium.org/wiki/index.php?title=Cefazolin&printable=yes
This editable Main Article is under development and subject to a disclaimer.
(CC) Image: David E. Volk
cefazolin
IUPAC name: see chemistry section
Synonyms: cefazoline, cephazolin, CEZ
Formula: C14H14N8O4S3
 Uses: antibiotic drug
 Properties: beta-lactam
 Hazards: see drug interactions
Mass (g/mol): CAS #:
454.5072 25953-19-9


Cefazolin, also called cefazoline, cephazolin or CEZ, is a semisynthetic cephalosporin antibiotic sold under the brand name Ancef®. It is primarily used to treat bacterial skin infections, but can be used to treat moderately severe bacterial infections involving the lungs, bones, joints, stomach, blood, heart valves or the urinary tract. It is effective against staphylococci and streptococci species of Gram-positive bacteria. It is given by IV (parenterally).

Retrieved from "https://citizendium.org/wiki/index.php?title=Cefazolin&oldid=453354"