Mezlocillin: Difference between revisions
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'''Mezlocillin''', brand name '''Mezlin®''', is a [[penicillin]]-like, beta-[[lactam]] antibiotic agent, used to treat serious gram–negative infections of the lungs, urinary tract, and skin. Mezlocillin use has been discontinued in the United States. Bacteria susceptible to mezlocillin include [[Bacteriodes]] species (including B. fragilis), [[E. coli]], [[Enterobacter]] species, [[H. influenzae]], [[Klebsiella]] species, [[Morganella morganii]], [[Pseudomonas]] species, [[Proteus mirabilis]], [[Streptococcus faecelis]], [[Peptococcus]] species, [[Peptostreptococcus]] species, , [[Serratia]] species, [[N. gonorrhoeae]], [[P. vulgaris]], and [[Providencia rettgeri]].[http://www.drugbank.ca/cgi-bin/getCard.cgi?CARD=DB00948.txt] | '''Mezlocillin''', brand name '''Mezlin®''', is a [[penicillin]]-like, beta-[[lactam]] antibiotic agent, used to treat serious gram–negative infections of the lungs, urinary tract, and skin. Mezlocillin use has been discontinued in the United States. Bacteria susceptible to mezlocillin include [[Bacteriodes]] species (including B. fragilis), [[E. coli]], [[Enterobacter]] species, [[H. influenzae]], [[Klebsiella]] species, [[Morganella morganii]], [[Pseudomonas]] species, [[Proteus mirabilis]], [[Streptococcus faecelis]], [[Peptococcus]] species, [[Peptostreptococcus]] species, , [[Serratia]] species, [[N. gonorrhoeae]], [[P. vulgaris]], and [[Providencia rettgeri]].[http://www.drugbank.ca/cgi-bin/getCard.cgi?CARD=DB00948.txt] | ||
Revision as of 07:34, 8 June 2009
Mezlocillin, brand name Mezlin®, is a penicillin-like, beta-lactam antibiotic agent, used to treat serious gram–negative infections of the lungs, urinary tract, and skin. Mezlocillin use has been discontinued in the United States. Bacteria susceptible to mezlocillin include Bacteriodes species (including B. fragilis), E. coli, Enterobacter species, H. influenzae, Klebsiella species, Morganella morganii, Pseudomonas species, Proteus mirabilis, Streptococcus faecelis, Peptococcus species, Peptostreptococcus species, , Serratia species, N. gonorrhoeae, P. vulgaris, and Providencia rettgeri.[1]
Mechanism of action
Mezlocillin works by binding to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, thereby inhibiting the last stage of bacterial cell wall synthesis, which in turn leads to autolysis of the cells by autolytic enzymes (autolysins).
Chemistry
This drug is a beta-lactam based drug, similar to all of the penicillin-like drugs. Its IUPAC chemical name is (2S,5R,6R)-3,3-dimethyl-6-[[(2R)-2-[(3-methylsulfonyl-2-oxoimidazolidine-1-carbonyl) amino]-2-phenylacetyl]amino]-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid and its chemical formula is C21H25N5O8S2 (MW=539.5819 g/mol).
External links
The most up-to-date information about Mezlocillin and other drugs can be found at the following sites.
- Mezlocillin - FDA approved drug information (drug label) from DailyMed (U.S. National Library of Medicine).
- Mezlocillin - Drug information for consumers from MedlinePlus (U.S. National Library of Medicine).
- Mezlocillin - Detailed information from DrugBank.