Delavirdine: Difference between revisions

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'''Delavirdine''' ('''DLV'''), also called '''SPP''', is an [[antiviral drug]] that is a non-nucleoside, reverse transcriptase inhibitor ([[nNRTI]]) specific for [[HIV]]-1.  It binds directly to reverse transcriptase catalytic site and blocks the DNA polymerase activity.  HIV-2 RT and eukaryotic (human, for example) DNA polymerases are not effected by this drug.  Rashes are the major side effect of delavirdine toxicity, and they should be reported to the attending physician. Rashes typically are resolved in two weeks or less, but patients with severe rash or rash accompanied by  fever, blistering, oral lesions, conjunctivitis, swelling, muscle or joint aches should discontinue medication and consult a physician.
'''Delavirdine''' ('''DLV'''), also called '''SPP''', is an [[antiviral drug]] that is a non-nucleoside, reverse transcriptase inhibitor ([[nNRTI]]) specific for [[HIV]]-1.  It binds directly to reverse transcriptase catalytic site and blocks the DNA polymerase activity.  HIV-2 RT and eukaryotic (human, for example) DNA polymerases are not effected by this drug.  Rashes are the major side effect of delavirdine toxicity, and they should be reported to the attending physician. Rashes typically are resolved in two weeks or less, but patients with severe rash or rash accompanied by  fever, blistering, oral lesions, conjunctivitis, swelling, muscle or joint aches should discontinue medication and consult a physician.
== Chemistry ==
Its chemical name is  N-[2-[4-[3-(propan-2-ylamino)pyridin-2-yl]piperazine-1-carbonyl]-1H-indol-
5-yl]methanesulfonamide and its chemical formula is C<sub>22</sub>H<sub>28</sub>N<sub>6</sub>O<sub>3</sub>S (Molecular Mass 456.5611).
== Drug interactions ==
The effect of delavirdine is decreased when used with [[St. John's Wort]], [[antacid]]s, some [[anticonvulsant]]s such as [[carbamazepine]], [[fosphenytoin]], [[methylphenobarbital]], [[phenobarbital]] and [[phentoin]], and with [[rifampin]] or [[rifabutin]].  [[Amprenavir]] and derivatives ([[Fosamprenavir]]) decrease delavirdine levels.
Delavirdine increases the effects and toxicity of [[benzodiazepine]] when taken with [[alprazolam]], [[midazolam]] or [[triazolam]] and also the effects of some [[statin]]s, including [[atorvastatin]], [[lovastatin]] and [[simvastatin]].  The toxicity of ergot may be a concern when delavirdine is taken with the ergot derivatives [[dihydroergotamine]], [[dihydroergotoxine]], [[ergonovine]], [[ergotamine]], [[methylergonovine]], and [[methysergide]].  An increased risk of cardiotoxicity and [[arrhythmia]]s are noted when delavirdine is taken with [[astemizole]], [[cisapride]] or [[terfenadine]]. The effects of the [[antiviral drugs]] [[indinavir]] and [[ritonavir]] are increased when taken with delavirdine. Increased toxicity is also noted with [[quinupristin]] and [[saquinavir]].
== External Links ==
* {{DailyMed}}
* {{MedMaster}}
* {{DrugBank}}

Revision as of 15:53, 5 April 2009

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Delavirdine structure.jpg
delavirdine
IUPAC name: see chemistry section
Synonyms: SPP
Formula: C22H28N6O3S
 Uses: HIV
 Properties: Reverse Transcriptase inhibitor
 Hazards: see drug interactions
Mass (g/mol): CAS #:
456.5611 136817-59-9



Delavirdine (DLV), also called SPP, is an antiviral drug that is a non-nucleoside, reverse transcriptase inhibitor (nNRTI) specific for HIV-1. It binds directly to reverse transcriptase catalytic site and blocks the DNA polymerase activity. HIV-2 RT and eukaryotic (human, for example) DNA polymerases are not effected by this drug. Rashes are the major side effect of delavirdine toxicity, and they should be reported to the attending physician. Rashes typically are resolved in two weeks or less, but patients with severe rash or rash accompanied by fever, blistering, oral lesions, conjunctivitis, swelling, muscle or joint aches should discontinue medication and consult a physician.

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