Gemfibrozil: Difference between revisions
imported>David E. Volk (brand names) |
imported>David E. Volk (Drug interactions) |
||
| Line 3: | Line 3: | ||
'''Gemfibrozil''', or 5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoic acid), is drug that lowers serum [[triglyceride]] levels, with variable effects on cholesterol. The [[VLDL]] fraction is preferentially lowered and LDL less so. The HDL subfractions HDL2 and HDL3, and [[apolipoprotein]]s A-I and A-II, are increased. Gemfibrozil is a [[fibric acid]] antilipemic drug similar to [[clofibrate]] that is used to treat [[hyperlipoproteinemia]] and supplimental therapy for type IIb [[hypercholesterolemia]]. Gemfibrozil increases lipoprotein triglyceride lipolysis by increasing the activity of extrahepatic [[lipoprotein lipase]]. Chylomicrons are degraded, VLDLs are converted to LDLs, and LDLs are converted to HDL. | '''Gemfibrozil''', or 5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoic acid), is drug that lowers serum [[triglyceride]] levels, with variable effects on cholesterol. The [[VLDL]] fraction is preferentially lowered and LDL less so. The HDL subfractions HDL2 and HDL3, and [[apolipoprotein]]s A-I and A-II, are increased. Gemfibrozil is a [[fibric acid]] antilipemic drug similar to [[clofibrate]] that is used to treat [[hyperlipoproteinemia]] and supplimental therapy for type IIb [[hypercholesterolemia]]. Gemfibrozil increases lipoprotein triglyceride lipolysis by increasing the activity of extrahepatic [[lipoprotein lipase]]. Chylomicrons are degraded, VLDLs are converted to LDLs, and LDLs are converted to HDL. | ||
== Drug Interactions == | |||
Gemfibrozil increases the anticoagulant effects of [[anisindione]], [[dicumarol]], [[acenocoumarol]] and [[warfarin]]. There is an increased risk of [[myopathy]]/[[rhaddomyolysis]] when gemfibrizol is taken with the cholesterol lowering statin drugs [[atorvastatin]] (Lipitor), [[cerivastatin]], [[fluvastatin]], [[lovastatin]], [[pravastatin]], and [[simvastatin]]. Gemfibrizol increases the effects and toxicity of [[pioglitazone]], [[rosiglitazone]] and [[repaglinide]]. The statin [[rosuvastatin may increase the effect of gemfibrizol, and gemfibrizol decreases the effects of [[ursodiol]]. | |||
== Brand Names == | == Brand Names == | ||
Revision as of 10:23, 25 January 2008
Gemfibrozil, or 5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoic acid), is drug that lowers serum triglyceride levels, with variable effects on cholesterol. The VLDL fraction is preferentially lowered and LDL less so. The HDL subfractions HDL2 and HDL3, and apolipoproteins A-I and A-II, are increased. Gemfibrozil is a fibric acid antilipemic drug similar to clofibrate that is used to treat hyperlipoproteinemia and supplimental therapy for type IIb hypercholesterolemia. Gemfibrozil increases lipoprotein triglyceride lipolysis by increasing the activity of extrahepatic lipoprotein lipase. Chylomicrons are degraded, VLDLs are converted to LDLs, and LDLs are converted to HDL.
Drug Interactions
Gemfibrozil increases the anticoagulant effects of anisindione, dicumarol, acenocoumarol and warfarin. There is an increased risk of myopathy/rhaddomyolysis when gemfibrizol is taken with the cholesterol lowering statin drugs atorvastatin (Lipitor), cerivastatin, fluvastatin, lovastatin, pravastatin, and simvastatin. Gemfibrizol increases the effects and toxicity of pioglitazone, rosiglitazone and repaglinide. The statin [[rosuvastatin may increase the effect of gemfibrizol, and gemfibrizol decreases the effects of ursodiol.
Brand Names
- Apo-Gemfibrozil
- Bolutol
- Cholespid
- Decrelip
- Fibratol
- Fibrocit
- Gemfibril
- Gemfibromax
- Gemlipid
- Gen-Fibro
- Genlip
- Gevilon
- Hipolixan
- Jezil
- Lipozid
- Lipur
- Lopid
- Novo-Gemfibrozil
- Nu-Gemfibrozil
External Links
- Gemfibrozil - FDA approved drug information (drug label) from DailyMed (U.S. National Library of Medicine).
- Drug Bank at http://www.drugbank.ca/cgi-bin/getCard.cgi?CARD=DB01241.txt