Number needed to treat: Difference between revisions

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The '''number needed to treat''' is a way of summarizing the benefit of an intervention to improve health care.<ref name="pmid3374545">{{cite journal |author=Laupacis A, Sackett DL, Roberts RS |title=An assessment of clinically useful measures of the consequences of treatment |journal=N. Engl. J. Med. |volume=318 |issue=26 |pages=1728–33 |year=1988 |pmid=3374545 |doi=}}</ref><ref name="pmid16174840">{{cite journal |author=Wen L, Badgett R, Cornell J |title=Number needed to treat: a descriptor for weighing therapeutic options |journal=Am J Health Syst Pharm |volume=62 |issue=19 |pages=2031–6 |year=2005 |pmid=16174840 |doi=10.2146/ajhp040558 |url=http://www.ajhp.org/cgi/pmidlookup?view=long&pmid=16174840}}</ref> The calculations are derived from the results of a [[randomized controlled trial]] of an intervention.
The '''number needed to treat''' ('''NNT''') is a way of summarizing the benefit of an intervention to improve health care.<ref name="pmid3374545">{{cite journal |author=Laupacis A, Sackett DL, Roberts RS |title=An assessment of clinically useful measures of the consequences of treatment |journal=N. Engl. J. Med. |volume=318 |issue=26 |pages=1728–33 |year=1988 |pmid=3374545 |doi=}}</ref><ref name="pmid16174840">{{cite journal |author=Wen L, Badgett R, Cornell J |title=Number needed to treat: a descriptor for weighing therapeutic options |journal=Am J Health Syst Pharm |volume=62 |issue=19 |pages=2031–6 |year=2005 |pmid=16174840 |doi=10.2146/ajhp040558 |url=http://www.ajhp.org/cgi/pmidlookup?view=long&pmid=16174840}}</ref> The NNT has been proposed to improve [[quantitative literacy]].<ref name="pmid3374545"/> The calculations are derived from the results of a [[randomized controlled trial]] of an intervention.


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The number needed to treat (NNT) is a way of summarizing the benefit of an intervention to improve health care.[1][2] The NNT has been proposed to improve quantitative literacy.[1] The calculations are derived from the results of a randomized controlled trial of an intervention.

Two-by-two table for a screening program
Outcome
Present Absent
Experimental (intervention) group Cell A Cell B Total in experimental group
Control group Cell C Cell D Total in control group
Total with outcome Total without outcome

Calculations

Event rates

Measures of efficacy

Example

References

  1. ↑ 1.0 1.1 Laupacis A, Sackett DL, Roberts RS (1988). "An assessment of clinically useful measures of the consequences of treatment". N. Engl. J. Med. 318 (26): 1728–33. PMID 3374545. [e]
  2. ↑ Wen L, Badgett R, Cornell J (2005). "Number needed to treat: a descriptor for weighing therapeutic options". Am J Health Syst Pharm 62 (19): 2031–6. DOI:10.2146/ajhp040558. PMID 16174840. Research Blogging.

See also

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