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== '''[[Warfarin]]''' ==
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''by [[User:Robert Badgett|Robert Badgett]], [[User:David E. Volk|David E. Volk]], and [[User:Chris Day|Chris Day]] <small>(and [[User:Caesar Schinas|Caesar Schinas]])</small>''
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==Footnotes==
{{Image|Warfarin structure.jpg|right|200px|Structure of Warfarin.}}  
 
'''[[Warfarin]]''' (IUPAC name
4-hydroxy-3-(3-oxo-1-phenylbutyl)-2H-chromen-2-one), also widely called coumadin, is an anticoagulant medication used prophylactically to suppress the formation of embolism and thrombosis from conditions such as atrial fibrillation, deep venous thrombosis, and pulmonary embolism.
 
Originally designed to be a rat poison, warfarin works as an anticoagulant by suppressing the enzyme epoxide reductase in the liver, thereby suppressing the formation of the reduced form of vitamin K epoxide, which is needed for the synthesis of many coagulation factors. As a drug, it is often sold as the sodium salt of warfarin.
 
===Discovery===
The dangers of feeding livestock spoiled sweet clover hay were known in the 1920’s<ref>Wardrop D, Keeling D (2008) The story of the discovery of heparin and warfarin ''Brit J Haematol'' 141:757-63</ref> and scientists at the University of Wisconsin-Madison were spearheading the problem on multiple fronts. R.A. Brink and W.K. Smith were attempting to breed a new variety of clover that was free of the toxic effect and Karl Paul Link's laboratory was attempting to isolate the killer compound. Farmers were already hurting due to the Great Depression and despite knowing they should not feed their livestock such hay, they could not afford to buy uncontaminated supplies. This disease that was affecting many livestock throughout the US became known as "sweet clover disease".<ref>Duxbury BM, Poller L (2001) The oral anticoagulant saga: past, present, and future ''Clin Appl Thrombosis/Hemostasis'' 7:269–75 PMID 11697707</ref>
 
''[[Warfarin|.... (read more)]]''
 
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Latest revision as of 09:19, 11 September 2020

After decades of failure to slow the rising global consumption of coal, oil and gas,[1] many countries have proceeded as of 2024 to reconsider nuclear power in order to lower the demand for fossil fuels.[2] Wind and solar power alone, without large-scale storage for these intermittent sources, are unlikely to meet the world's needs for reliable energy.[3][4][5] See Figures 1 and 2 on the magnitude of the world energy challenge.

Nuclear power plants that use nuclear reactors to create electricity could provide the abundant, zero-carbon, dispatchable[6] energy needed for a low-carbon future, but not by simply building more of what we already have. New innovative designs for nuclear reactors are needed to avoid the problems of the past.

(CC) Image: Geoff Russell
Fig.1 Electricity consumption may soon double, mostly from coal-fired power plants in the developing world.[7]

Issues Confronting the Nuclear Industry

New reactor designers have sought to address issues that have prevented the acceptance of nuclear power, including safety, waste management, weapons proliferation, and cost. This article will summarize the questions that have been raised and the criteria that have been established for evaluating these designs. Answers to these questions will be provided by the designers of these reactors in the articles on their designs. Further debate will be provided in the Discussion and the Debate Guide pages of those articles.

Footnotes

  1. Global Energy Growth by Our World In Data
  2. Countries, organizations, and public figures that have reconsidered their stance on nuclear power are listed on the External Links tab of this article.
  3. Pumped storage is currently the most economical way to store electricity, but it requires a large reservoir on a nearby hill or in an abandoned mine. Li-ion battery systems at $500 per KWh are not practical for utility-scale storage. See Energy Storage for a summary of other alternatives.
  4. Utilities that include wind and solar power in their grid must have non-intermittent generating capacity (typically fossil fuels) to handle maximum demand for several days. They can save on fuel, but the cost of the plant is the same with or without intermittent sources.
  5. Mark Jacobson believes that long-distance transmission lines can provide an alternative to costly storage. See the bibliography for more on this proposal and the critique by Christopher Clack.
  6. "Load following" is the term used by utilities, and is important when there is a lot of wind and solar on the grid. Some reactors are not able to do this.
  7. Fig.1.3 in Devanney "Why Nuclear Power has been a Flop"