Tetrahydrofolate dehydrogenase/Definition: Difference between revisions

From Citizendium
Jump to navigation Jump to search
imported>Howard C. Berkowitz
(New page: <noinclude>{{Subpages}}</noinclude> An enzyme of the oxidoreductase class that catalyzes the reaction 7,8-dihyrofolate and NADPH to yield 5,6,7,8-tetrahydrofolate and NADPH+, producing red...)
 
imported>Howard C. Berkowitz
No edit summary
 
Line 1: Line 1:
<noinclude>{{Subpages}}</noinclude>
<noinclude>{{Subpages}}</noinclude>
An enzyme of the oxidoreductase class that catalyzes the reaction 7,8-dihyrofolate and NADPH to yield 5,6,7,8-tetrahydrofolate and NADPH+, producing reduced folate for amino acid metabolism, purine ring synthesis, and the formation of deoxythymidine monophosphate. [[Methotrexate]] and other [[folic acid antagonist]]s used as chemotherapeutic drugs act by inhibiting this enzyme. Also known as [[dihydrofolate dehydrogenase]], [[dihydrofolate reductase]] and [[folic acid reductase]]; differs from [[methylenetetrahydrofolate reductase]] <noinclude>{{DefMeSH}}</noinclude>
An enzyme of the oxidoreductase class that catalyzes the reaction 7,8-dihydrofolate and NADPH to yield 5,6,7,8-tetrahydrofolate and [[NADPH]]+, producing reduced folate for [[amino acid]] metabolism, [[purine]] ring synthesis, and the formation of deoxythymidine monophosphate. [[Methotrexate]] and other [[folic acid antagonist]]s used as chemotherapeutic drugs act by inhibiting this enzyme. Also known as [[dihydrofolate dehydrogenase]], [[dihydrofolate reductase]] and [[folic acid reductase]]; differs from [[methylenetetrahydrofolate reductase]] <noinclude>{{DefMeSH}}</noinclude>

Latest revision as of 13:25, 27 May 2010

This article contains just a definition and optionally other subpages (such as a list of related articles), but no metadata. Create the metadata page if you want to expand this into a full article.


Tetrahydrofolate dehydrogenase [r]: An enzyme of the oxidoreductase class that catalyzes the reaction 7,8-dihydrofolate and NADPH to yield 5,6,7,8-tetrahydrofolate and NADPH+, producing reduced folate for amino acid metabolism, purine ring synthesis, and the formation of deoxythymidine monophosphate. Methotrexate and other folic acid antagonists used as chemotherapeutic drugs act by inhibiting this enzyme. Also known as dihydrofolate dehydrogenase, dihydrofolate reductase and folic acid reductase; differs from methylenetetrahydrofolate reductase

This definition is at least in part based on: Anonymous (2024), Tetrahydrofolate dehydrogenase (English). Medical Subject Headings. U.S. National Library of Medicine.