Diabetic nephropathy: Difference between revisions
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In [[medicine]], '''diabetic nephropathies''', also called Kimmelstiel-Wilson Disease and glomerulosclerosis, are "kidney injuries associated with diabetes mellitus and affecting kidney glomerulus; arterioles; kidney tubules; and the interstitium. Clinical signs include persistent [[proteinuria]], from [[microalbuminuria]] progressing to [[albuminuria]] of greater than 300 mg/24 h, leading to reduced [[glomerular filtration rate]] and end-stage renal disease."<ref>{{MeSH}}</ref> | In [[medicine]], '''diabetic nephropathies''', also called Kimmelstiel-Wilson Disease and glomerulosclerosis, are "kidney injuries associated with diabetes mellitus and affecting kidney glomerulus; arterioles; kidney tubules; and the interstitium. Clinical signs include persistent [[proteinuria]], from [[microalbuminuria]] progressing to [[albuminuria]] of greater than 300 mg/24 h, leading to reduced [[glomerular filtration rate]] and end-stage renal disease."<ref>{{MeSH}}</ref> | ||
==Prevention== | ==Prevention== | ||
[[Telmisartan]], an [[angiotensin II type 1 receptor blocker]], slows the increase in [[albuminuria]] but may worsen the serum creatinine and [[glomerular filtration rate]].<ref>Mann JF et al. | [[Telmisartan]], an [[angiotensin II type 1 receptor blocker]], slows the increase in [[albuminuria]] but may worsen the serum creatinine and [[glomerular filtration rate]].<ref name="pmid19451556">{{cite journal| author=Mann JF, Schmieder RE, Dyal L, McQueen MJ, Schumacher H, Pogue J et al.| title=Effect of telmisartan on renal outcomes: a randomized trial. | journal=Ann Intern Med | year= 2009 | volume= 151 | issue= 1 | pages= 1-10, W1-2 | pmid=19451556 | ||
| url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=19451556 }} <!--Formatted by http://sumsearch.uthscsa.edu/cite/--></ref> | |||
==Treatment== | |||
Diabetic nephropathy might be reversible after [[pancreas transplantation]].<ref name="pmid9654536">{{cite journal| author=Fioretto P, Steffes MW, Sutherland DE, Goetz FC, Mauer M| title=Reversal of lesions of diabetic nephropathy after pancreas transplantation. | journal=N Engl J Med | year= 1998 | volume= 339 | issue= 2 | pages= 69-75 | pmid=9654536 | |||
| url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=9654536 }} <!--Formatted by http://sumsearch.uthscsa.edu/cite/--></ref> | |||
==References== | ==References== | ||
<references/> | <references/>[[Category:Suggestion Bot Tag]] | ||
Latest revision as of 16:00, 6 August 2024
In medicine, diabetic nephropathies, also called Kimmelstiel-Wilson Disease and glomerulosclerosis, are "kidney injuries associated with diabetes mellitus and affecting kidney glomerulus; arterioles; kidney tubules; and the interstitium. Clinical signs include persistent proteinuria, from microalbuminuria progressing to albuminuria of greater than 300 mg/24 h, leading to reduced glomerular filtration rate and end-stage renal disease."[1]
Prevention
Telmisartan, an angiotensin II type 1 receptor blocker, slows the increase in albuminuria but may worsen the serum creatinine and glomerular filtration rate.[2]
Treatment
Diabetic nephropathy might be reversible after pancreas transplantation.[3]
References
- ↑ Anonymous (2024), Diabetic nephropathy (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ Mann JF, Schmieder RE, Dyal L, McQueen MJ, Schumacher H, Pogue J et al. (2009). "Effect of telmisartan on renal outcomes: a randomized trial.". Ann Intern Med 151 (1): 1-10, W1-2. PMID 19451556.
- ↑ Fioretto P, Steffes MW, Sutherland DE, Goetz FC, Mauer M (1998). "Reversal of lesions of diabetic nephropathy after pancreas transplantation.". N Engl J Med 339 (2): 69-75. PMID 9654536.