Metoclopramide: Difference between revisions
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In '''medicine''', [[metoclopramide]] is a " dopamine D2 antagonist that is used as an [[antiemetic agent|antiemetic]] | In '''medicine''', [[metoclopramide]] is a " dopamine D2 antagonist that is used as an [[antiemetic agent|antiemetic]],"<ref>{{MeSH}}</ref> often in [[emergency medicine]]. | ||
In a [[randomized controlled trial]] that compared [[droperidol]], [[metoclopramide]], and [[prochlorperazine]], droperidol was more effective but also caused more self-reported [[anxiety]] or restlessness.<ref name="pmid16490647">Braude D et al. Antiemetics in the ED: a randomized controlled trial comparing 3 common agents. Am J Emerg Med. 2006 Mar;24(2):177-82. PMID 16490647</ref> | In a [[randomized controlled trial]] that compared [[droperidol]], [[metoclopramide]], and [[prochlorperazine]], droperidol was more effective but also caused more self-reported [[anxiety]] or restlessness.<ref name="pmid16490647">Braude D et al. Antiemetics in the ED: a randomized controlled trial comparing 3 common agents. Am J Emerg Med. 2006 Mar;24(2):177-82. PMID 16490647</ref> | ||
Metoclopramide may cause [[psychomotor agitation]], this is not prevented by [[diphenhydramine]].<ref name="pmid18814935">{{cite journal |author=Friedman BW, Bender B, Davitt M, ''et al'' |title=A randomized trial of diphenhydramine as prophylaxis against metoclopramide-induced akathisia in nauseated emergency department patients |journal=Ann Emerg Med |volume=53 |issue=3 |pages=379–85 |year=2009 |month=March |pmid=18814935 |doi=10.1016/j.annemergmed.2008.08.003 |url=http://linkinghub.elsevier.com/retrieve/pii/S0196-0644(08)01586-2 |issn=}}</ref> | Metoclopramide may cause [[psychomotor agitation]], this is not prevented by [[diphenhydramine]].<ref name="pmid18814935">{{cite journal |author=Friedman BW, Bender B, Davitt M, ''et al'' |title=A randomized trial of diphenhydramine as prophylaxis against metoclopramide-induced akathisia in nauseated emergency department patients |journal=Ann Emerg Med |volume=53 |issue=3 |pages=379–85 |year=2009 |month=March |pmid=18814935 |doi=10.1016/j.annemergmed.2008.08.003 |url=http://linkinghub.elsevier.com/retrieve/pii/S0196-0644(08)01586-2 |issn=}}</ref> | ||
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==References== | ==References== | ||
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Latest revision as of 09:19, 22 October 2024
In medicine, metoclopramide is a " dopamine D2 antagonist that is used as an antiemetic,"[1] often in emergency medicine.
In a randomized controlled trial that compared droperidol, metoclopramide, and prochlorperazine, droperidol was more effective but also caused more self-reported anxiety or restlessness.[2]
Metoclopramide may cause psychomotor agitation, this is not prevented by diphenhydramine.[3]
Attribution
- Some content on this page may previously have appeared on Wikipedia.
References
- ↑ Anonymous (2024), Metoclopramide (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ Braude D et al. Antiemetics in the ED: a randomized controlled trial comparing 3 common agents. Am J Emerg Med. 2006 Mar;24(2):177-82. PMID 16490647
- ↑ Friedman BW, Bender B, Davitt M, et al (March 2009). "A randomized trial of diphenhydramine as prophylaxis against metoclopramide-induced akathisia in nauseated emergency department patients". Ann Emerg Med 53 (3): 379–85. DOI:10.1016/j.annemergmed.2008.08.003. PMID 18814935. Research Blogging.