Bradykinin receptor: Difference between revisions
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Latest revision as of 06:00, 21 July 2024
Bradykinin receptors are "cell surface receptors that bind bradykinin and related kinins with high affinity and trigger intracellular changes which influence the behavior of cells. The identified receptor types (B-1 and B-2, or BK-1 and BK-2) recognize endogenous kallidin; t-kinins; and certain bradykinin fragments as well as bradykinin itself."[1]
Bradykinin receptors are G-Protein-coupled cell surface receptors.
Classification
Bradykinin B1 receptor
"A subtype of bradykinin receptor that is induced in response to inflammation. It may play a role in chronic inflammation and has a high specificity for kinins lacking the C-terminal arginine such as des-Arg(10)-kallidin and des-Arg(9)-bradykinin. The receptor is coupled to G-Protein, GQ-G11 alpha family and G-Protein, GI-GO alpha family signaling proteins."[2]
Bradykinin B2 receptor
"A constitutively expressed subtype of bradykinin receptor that may play a role in the acute phase of the inflammatory and pain response. It has high specificity for intact forms of bradykinin and kallidin. The receptor is coupled to G-Protein, GQ-G11 alpha family and G-Protein, GI-GO alpha family signaling proteins."[3]
References
- ↑ Anonymous (2024), Bradykinin receptor (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ Anonymous (2024), Bradykinin B1 receptor (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ Anonymous (2024), Bradykinin B2 receptor (English). Medical Subject Headings. U.S. National Library of Medicine.