Rosuvastatin: Difference between revisions

From Citizendium
Jump to navigation Jump to search
imported>David E. Volk
(New page: {{subpages}} [[Image:Rosuvastatin structure.jpg|right|thumb|200px|{{#ifexist:Template:Rosuvastatin structure.jpg/credit|{{Rosuvastatin structure.jpg/credit}}<br/>|}}Rosuvastatin, a class I...)
 
mNo edit summary
 
(11 intermediate revisions by 4 users not shown)
Line 1: Line 1:
{{subpages}}
{{subpages}}
[[Image:Rosuvastatin structure.jpg|right|thumb|200px|{{#ifexist:Template:Rosuvastatin structure.jpg/credit|{{Rosuvastatin structure.jpg/credit}}<br/>|}}Rosuvastatin, a class II statin.]]
{{Image|Rosuvastatin structure.jpg|right|350px|Rosuvastatin, a type II statin.}}


'''Rosuvastatin''', marketed as '''Crestor''',  is a class II statin used to treat high cholesterol levels ([[hypercholesterolemia]]), prevent [[myocardial infarction|heart attacks]] and [[stroke]]s, and to diminish the formation of [[atherosclerosis|arterial plaque]].  It is a [[Hydroxymethylglutaryl-coenzyme A reductase inhibitor|HMG-CoA reductase inhibitor]] that decreases the conversion of HMG-CoA to  [[mevalonate]], a key chemical precursor of [[cholesterol]].   
'''Rosuvastatin''', marketed as '''Crestor''',  is a type II [[statin]] used to treat high cholesterol levels ([[hypercholesterolemia]]), prevent [[myocardial infarction|heart attacks]] and [[stroke]]s, and to diminish the formation of [[atherosclerosis|arterial plaque]].  It is a [[Hydroxymethylglutaryl-coenzyme A reductase inhibitor|HMG-CoA reductase inhibitor]] that decreases the conversion of HMG-CoA to  [[mevalonate]], a key chemical precursor of [[cholesterol]].  It is related to other type II statins such as [[fluvastatin]] and [[atorvastatin]].


Its official chemical IUPAC name is (E,3R,5R)-7-[4-(4-fluorophenyl)-2-(methyl-methylsulfonylamino)-6-propan-2-ylpyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic acid and its chemical formula is C<sub>22</sub>H<sub>28</sub>FN<sub>3</sub>O<sub>6</sub>S.
Its official chemical IUPAC name is (E,3R,5R)-7-[4-(4-fluorophenyl)-2-(methyl-methylsulfonylamino)-6-propan-2-ylpyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic acid and its chemical formula is C<sub>22</sub>H<sub>28</sub>FN<sub>3</sub>O<sub>6</sub>S.
==History==
Crestor brand of rosuvastatin was approved for Merck and Schering-Plough by the [[Food and Drug Administration]] in the [[United States of America]] with a [http://www.fda.gov/Drugs/DevelopmentApprovalProcess/HowDrugsareDevelopedandApproved/ApprovalApplications/NewDrugApplicationNDA/ New Drug Application] (NDA) in 2003.<ref>{{FDA-Drug_Details|021366}}</ref> A generic version of rosuvastatin calcium with a AB [[Food and Drug  Administration/Catalogs/Therapeutic Equivalence Code|Therapeutic Equivalence Code]] was approved for Mylan Pharma with a [http://www.fda.gov/Drugs/DevelopmentApprovalProcess/HowDrugsareDevelopedandApproved/ApprovalApplications/AbbreviatedNewDrugApplicationANDAGenerics/ Abbreviated New Drug Application] (ANDA) in 2010.<ref>{{FDA-Drug_Details|079161}}</ref> A generic version of rosuvastatin  zinc with a AB [[Food and Drug  Administration/Catalogs/Therapeutic Equivalence Code|Therapeutic Equivalence Code]] was approved for Watson Labs with a [http://www.fda.gov/Drugs/DevelopmentApprovalProcess/HowDrugsareDevelopedandApproved/ApprovalApplications/AbbreviatedNewDrugApplicationANDAGenerics/ Abbreviated New Drug Application] (ANDA) in 2011.<ref>{{FDA-Drug_Details|202172}}</ref>
==External links==
{{CZMed|Rosuvastatin|6087}}
==References==
<references/>[[Category:Suggestion Bot Tag]]

Latest revision as of 12:01, 13 October 2024

This article is developing and not approved.
Main Article
Discussion
Related Articles  [?]
Bibliography  [?]
External Links  [?]
Citable Version  [?]
 
This editable Main Article is under development and subject to a disclaimer.
(CC) Image: David E. Volk
Rosuvastatin, a type II statin.

Rosuvastatin, marketed as Crestor, is a type II statin used to treat high cholesterol levels (hypercholesterolemia), prevent heart attacks and strokes, and to diminish the formation of arterial plaque. It is a HMG-CoA reductase inhibitor that decreases the conversion of HMG-CoA to mevalonate, a key chemical precursor of cholesterol. It is related to other type II statins such as fluvastatin and atorvastatin.

Its official chemical IUPAC name is (E,3R,5R)-7-[4-(4-fluorophenyl)-2-(methyl-methylsulfonylamino)-6-propan-2-ylpyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic acid and its chemical formula is C22H28FN3O6S.

History

Crestor brand of rosuvastatin was approved for Merck and Schering-Plough by the Food and Drug Administration in the United States of America with a New Drug Application (NDA) in 2003.[1] A generic version of rosuvastatin calcium with a AB Therapeutic Equivalence Code was approved for Mylan Pharma with a Abbreviated New Drug Application (ANDA) in 2010.[2] A generic version of rosuvastatin zinc with a AB Therapeutic Equivalence Code was approved for Watson Labs with a Abbreviated New Drug Application (ANDA) in 2011.[3]

External links

The most up-to-date information about Rosuvastatin and other drugs can be found at the following sites.


References

  1. Anonymous. Drugs@FDA for FDA Application No. 021366. U S Food and Drug Administration
  2. Anonymous. Drugs@FDA for FDA Application No. 079161. U S Food and Drug Administration
  3. Anonymous. Drugs@FDA for FDA Application No. 202172. U S Food and Drug Administration