Hypoalphalipoproteinemia: Difference between revisions
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'''Hypoalphalipoproteinemias''', also called ''familial high density lipoprotein deficiency disease'' and ''HDL lipoprotein deficiency disease'', are defined as "conditions with abnormally low levels of alpha-lipoproteins (high-density | '''Hypoalphalipoproteinemias''', also called ''familial high density lipoprotein deficiency disease'' and ''[[HDL]] lipoprotein deficiency disease'', are defined as "conditions with abnormally low levels of alpha-lipoproteins ([[high-density lipoprotein]]s) in the blood. Hypoalphalipoproteinemia can be associated with mutations in genes encoding [[apolipoprotein A-I]]; [[lecithin cholesterol acyltransferase]]; and ATP-binding cassette transporters."<ref name="MeSH-Hypoalphalipoproteinemias">{{MeSH}}</ref> This causes [[hypertriglyceridemia]]. | ||
==Treatment== | ==Treatment== | ||
Using [[gemfibrozil]] to treat hypoalphalipoproteinemia may reduce major cardiovascular events<ref name="pmid10438259">{{cite journal |author=Rubins HB, Robins SJ, Collins D, ''et al'' |title=Gemfibrozil for the secondary prevention of coronary heart disease in men with low levels of high-density lipoprotein cholesterol. Veterans Affairs High-Density Lipoprotein Cholesterol Intervention Trial Study Group |journal=N. Engl. J. Med. |volume=341 |issue=6 |pages=410–8 |year=1999 |pmid=10438259 |doi= |issn=|url=http://content.nejm.org/cgi/content/full/341/6/410}}</ref> and [[stroke]]<ref name="pmid11401940">{{cite journal |author=Bloomfield Rubins H, Davenport J, Babikian V, ''et al'' |title=Reduction in stroke with gemfibrozil in men with coronary heart disease and low HDL cholesterol: The Veterans Affairs HDL Intervention Trial (VA-HIT) |journal=Circulation |volume=103 |issue=23 |pages=2828–33 |year=2001 |pmid=11401940 |doi= |issn=}}</ref> and in men with known men with known [[coronary heart disease]]. | Using [[gemfibrozil]] to treat hypoalphalipoproteinemia may reduce major cardiovascular events<ref name="pmid10438259">{{cite journal |author=Rubins HB, Robins SJ, Collins D, ''et al'' |title=Gemfibrozil for the secondary prevention of coronary heart disease in men with low levels of high-density lipoprotein cholesterol. Veterans Affairs High-Density Lipoprotein Cholesterol Intervention Trial Study Group |journal=N. Engl. J. Med. |volume=341 |issue=6 |pages=410–8 |year=1999 |pmid=10438259 |doi= |issn=|url=http://content.nejm.org/cgi/content/full/341/6/410}}</ref> and [[stroke]]<ref name="pmid11401940">{{cite journal |author=Bloomfield Rubins H, Davenport J, Babikian V, ''et al'' |title=Reduction in stroke with gemfibrozil in men with coronary heart disease and low HDL cholesterol: The Veterans Affairs HDL Intervention Trial (VA-HIT) |journal=Circulation |volume=103 |issue=23 |pages=2828–33 |year=2001 |pmid=11401940 |doi= |issn=}}</ref> and in men with known men with known [[coronary heart disease]]. | ||
Using [[simvastatin]] plus [[niacin]] to treat hypoalphalipoproteinemia may reduce cardiovascular event in men with [[coronary heart disease]].<ref name="pmid11757504">{{cite journal |author=Brown BG, Zhao XQ, Chait A, ''et al'' |title=Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease |journal=N. Engl. J. Med. |volume=345 |issue=22 |pages=1583–92 |year=2001 |pmid=11757504 |doi= |issn=}}</ref> | Using [[simvastatin]] plus [[niacin]] to treat hypoalphalipoproteinemia may reduce cardiovascular event in men with [[coronary heart disease]].<ref name="pmid11757504">{{cite journal |author=Brown BG, Zhao XQ, Chait A, ''et al'' |title=Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease |journal=N. Engl. J. Med. |volume=345 |issue=22 |pages=1583–92 |year=2001 |pmid=11757504 |doi= |issn=}}</ref> | ||
==References== | ==References== | ||
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Latest revision as of 16:00, 30 August 2024
Hypoalphalipoproteinemias, also called familial high density lipoprotein deficiency disease and HDL lipoprotein deficiency disease, are defined as "conditions with abnormally low levels of alpha-lipoproteins (high-density lipoproteins) in the blood. Hypoalphalipoproteinemia can be associated with mutations in genes encoding apolipoprotein A-I; lecithin cholesterol acyltransferase; and ATP-binding cassette transporters."[1] This causes hypertriglyceridemia.
Treatment
Using gemfibrozil to treat hypoalphalipoproteinemia may reduce major cardiovascular events[2] and stroke[3] and in men with known men with known coronary heart disease.
Using simvastatin plus niacin to treat hypoalphalipoproteinemia may reduce cardiovascular event in men with coronary heart disease.[4]
References
- ↑ Anonymous (2024), Hypoalphalipoproteinemia (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ Rubins HB, Robins SJ, Collins D, et al (1999). "Gemfibrozil for the secondary prevention of coronary heart disease in men with low levels of high-density lipoprotein cholesterol. Veterans Affairs High-Density Lipoprotein Cholesterol Intervention Trial Study Group". N. Engl. J. Med. 341 (6): 410–8. PMID 10438259. [e]
- ↑ Bloomfield Rubins H, Davenport J, Babikian V, et al (2001). "Reduction in stroke with gemfibrozil in men with coronary heart disease and low HDL cholesterol: The Veterans Affairs HDL Intervention Trial (VA-HIT)". Circulation 103 (23): 2828–33. PMID 11401940. [e]
- ↑ Brown BG, Zhao XQ, Chait A, et al (2001). "Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease". N. Engl. J. Med. 345 (22): 1583–92. PMID 11757504. [e]