Dengue fever: Difference between revisions
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'''Dengue fever''' is a viral disease transmitted by mosquitoes and is endemic in tropical and subtropical regions.<ref>{{cite web |url=http://www.searo.who.int/en/Section10/Section332_12647.htm |title=Dengue Fever - Information Sheet |accessdate=2007-10-09 |format= |work=}}</ref><ref name="pmid16135837">{{cite journal |author=Wilder-Smith A, Schwartz E |title=Dengue in travelers |journal=N. Engl. J. Med. |volume=353 |issue=9 |pages=924–32 |year=2005 |pmid=16135837 |doi=10.1056/NEJMra041927}}</ref> Because of the severe [[myalgia|myalgias]] and [[arthralgia|arthralgias]], it has been called "breakbone fever". Dengue fever is most prevalent in southeast Asia, but also occurs in Africa, Europe, South America, and southern regions of North America (South Texas).<ref name="pmid17115561">{{cite journal |author=Ramos M, Abell A, Smith B |title=Dengue and South Texas: information for clinicians |journal=Texas medicine |volume=102 |issue=8 |pages=56–8 |year=2006 |pmid=17115561 |doi=}}</ref> It may also occur in non-endemic regions in travelers from endemic regions.<ref name="pmid16135837" | {{subpages}}{{Taxobox | color=violet | ||
| name = ''Dengue virus'' | |||
| virus_group = iv | |||
| familia = ''[[Flaviviridae]]'' | |||
| genus = ''[[Flavivirus]]'' | |||
| species = '''''Dengue virus''''' | |||
| vectors = ''[[Aedis aegypti]]''<br> ''[[Aedis albopictus]]'' | |||
}} | |||
'''Dengue fever''' is a viral disease transmitted by mosquitoes and is endemic in tropical and subtropical regions.<ref>{{cite web |url=http://www.searo.who.int/en/Section10/Section332_12647.htm |title=Dengue Fever - Information Sheet |accessdate=2007-10-09 |format= |work=|author=World Health Organization}}</ref><ref name="pmid16135837">{{cite journal |author=Wilder-Smith A, Schwartz E |title=Dengue in travelers |journal=N. Engl. J. Med. |volume=353 |issue=9 |pages=924–32 |year=2005 |pmid=16135837 |doi=10.1056/NEJMra041927|url=http://content.nejm.org/cgi/content/full/353/9/924}}</ref><ref name="pmidpending">David M. Morens and Anthony S. Fauci, “Dengue and Hemorrhagic Fever: A Potential Threat to Public Health in the United States,” JAMA 299, no. 2 (January 9, 2008), http://jama.ama-assn.org (accessed January 10, 2008).</ref> Because of the severe [[myalgia|myalgias]] and [[arthralgia|arthralgias]], it has been called "breakbone fever". Dengue fever is most prevalent in southeast Asia, but also occurs in Africa, Europe, South America, and southern regions of North America (South Texas).<ref name="pmid17115561">{{cite journal |author=Ramos M, Abell A, Smith B |title=Dengue and South Texas: information for clinicians |journal=Texas medicine |volume=102 |issue=8 |pages=56–8 |year=2006 |pmid=17115561 |doi=}}</ref> It may also occur in non-endemic regions in travelers from endemic regions.<ref name="pmid16135837" /> | |||
==Classification== | ==Classification== | ||
===Primary versus secondary versus tertiary infection=== | |||
There are four serotypes of dengue. An initial infection is primary Dengue, a subsequent infection with a second serotype is secondary Dengue, and so on.<ref name="pmid11892494">{{cite journal |author=Guzmán MG, Kourí G |title=Dengue: an update |journal=The Lancet infectious diseases |volume=2 |issue=1 |pages=33–42 |year=2002 |pmid=11892494 |doi=}}</ref> In primary infection, I<sub>g</sub>M [[antibody|antibodies]] rise after 5–6 days and may last 2-3 months; I<sub>g</sub>G antibodies rise after 7–10 days. During a secondary infection very high levels of IgG may occur during the acute phase whereas I<sub>g</sub>M are lower and sometimes absent.<ref name="pmid11892494"/> | |||
Secondary Dengue can be more severe and is associated with thrombocytopenia.<ref name="pmid17593497">{{cite journal |author=Oishi K, Saito M, Mapua CA, Natividad FF |title=Dengue illness: clinical features and pathogenesis |journal=J. Infect. Chemother. |volume=13 |issue=3 |pages=125–33 |year=2007 |pmid=17593497 |doi=10.1007/s10156-007-0516-9}}</ref> Most cases of [[Dengue hemorrhagic fever]] occur in secondary Dengue.<ref name="pmid17593497"/> | |||
===Clinical syndromes=== | |||
The World Health Organization has classified Dengue fever as:<ref name="pmid16829301">{{cite journal |author=Deen JL, Harris E, Wills B, ''et al'' |title=The WHO dengue classification and case definitions: time for a reassessment |journal=Lancet |volume=368 |issue=9530 |pages=170–3 |year=2006 |pmid=16829301 |doi=10.1016/S0140-6736(06)69006-5}}</ref> | The World Health Organization has classified Dengue fever as:<ref name="pmid16829301">{{cite journal |author=Deen JL, Harris E, Wills B, ''et al'' |title=The WHO dengue classification and case definitions: time for a reassessment |journal=Lancet |volume=368 |issue=9530 |pages=170–3 |year=2006 |pmid=16829301 |doi=10.1016/S0140-6736(06)69006-5}}</ref> | ||
* '''Undifferentiated fever''' (viral syndrome) | * '''Undifferentiated fever''' (viral syndrome). Patients may have fever, severe headache, retro-orbital pain, fatigue, rash, and severe myalgia and arthralgia ("breakbone fever"). Patients may also have lymphadenopathy, injected conjunctivae, and mild respiratory and gastrointestinal symptoms.<ref name="pmid16135837"/> | ||
* '''Dengue fever syndrome''' has at least two of: 1) headache; 2)retro-orbital pain; 3) myalgia, 4) arthralgia; 4) rash; 5) [[hemorrhagic]] manifestations; 6) [[leucopenia]]. There must be other confirmed cases of dengue fever in the geographic area. | * '''Dengue fever syndrome''' has at least two of: 1) headache; 2)retro-orbital pain; 3) myalgia, 4) arthralgia; 4) rash; 5) [[hemorrhagic]] manifestations; 6) [[leucopenia]]. There must be other confirmed cases of dengue fever in the geographic area. | ||
* '''[[Dengue hemorrhagic fever]]''' (plasma leakage) must meet four of the following criteria: 1) fever or history of fever lasting 2–7 days; 2) positive tourniquet test or spontaneous bleeding; 3) [[platelet]] count 100x10<sup>9</sup>/L or less; 4) plasma leakage shown either by hemoconcentration with changes in packed-cell volume, or by the development of [[pleural effusions]] or [[ascites]]. | * '''[[Dengue hemorrhagic fever]]''' (plasma leakage) must meet four of the following criteria: 1) fever or history of fever lasting 2–7 days; 2) positive tourniquet test or spontaneous bleeding; 3) [[platelet]] count 100x10<sup>9</sup>/L or less; 4) plasma leakage shown either by hemoconcentration with changes in packed-cell volume, or by the development of [[pleural effusions]] or [[ascites]]. | ||
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* [[Glucocorticoids]] are of uncertain benefit.<ref name="pmid16135283">{{cite journal |author=Alejandria M |title=Dengue fever |journal=Clinical evidence |volume= |issue=13 |pages=887–95 |year=2005 |pmid=16135283 |doi=|url=http://clinicalevidence.bmj.com/ceweb/conditions/ind/0917/0917.jsp}}</ref> | * [[Glucocorticoids]] are of uncertain benefit.<ref name="pmid16135283">{{cite journal |author=Alejandria M |title=Dengue fever |journal=Clinical evidence |volume= |issue=13 |pages=887–95 |year=2005 |pmid=16135283 |doi=|url=http://clinicalevidence.bmj.com/ceweb/conditions/ind/0917/0917.jsp}}</ref> | ||
== | == Causative agent == | ||
Dengue fever is caused by infection of one of the four Dengue fever | Dengue fever is caused by infection of one of the four Dengue fever viral serotypes (DEN-1, DEN-2, DEN-3, and DEN-4).<ref name="pmid17593497"/> The Dengue fever viruses are classified as [[flavivirus]]es (family Flaviviridae, genus Dengue). | ||
==References== | ==References== | ||
<references/> | <references/>[[Category:Suggestion Bot Tag]] | ||
[[Category: | |||
Latest revision as of 07:01, 6 August 2024
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Dengue fever is a viral disease transmitted by mosquitoes and is endemic in tropical and subtropical regions.[1][2][3] Because of the severe myalgias and arthralgias, it has been called "breakbone fever". Dengue fever is most prevalent in southeast Asia, but also occurs in Africa, Europe, South America, and southern regions of North America (South Texas).[4] It may also occur in non-endemic regions in travelers from endemic regions.[2]
Classification
Primary versus secondary versus tertiary infection
There are four serotypes of dengue. An initial infection is primary Dengue, a subsequent infection with a second serotype is secondary Dengue, and so on.[5] In primary infection, IgM antibodies rise after 5–6 days and may last 2-3 months; IgG antibodies rise after 7–10 days. During a secondary infection very high levels of IgG may occur during the acute phase whereas IgM are lower and sometimes absent.[5]
Secondary Dengue can be more severe and is associated with thrombocytopenia.[6] Most cases of Dengue hemorrhagic fever occur in secondary Dengue.[6]
Clinical syndromes
The World Health Organization has classified Dengue fever as:[7]
- Undifferentiated fever (viral syndrome). Patients may have fever, severe headache, retro-orbital pain, fatigue, rash, and severe myalgia and arthralgia ("breakbone fever"). Patients may also have lymphadenopathy, injected conjunctivae, and mild respiratory and gastrointestinal symptoms.[2]
- Dengue fever syndrome has at least two of: 1) headache; 2)retro-orbital pain; 3) myalgia, 4) arthralgia; 4) rash; 5) hemorrhagic manifestations; 6) leucopenia. There must be other confirmed cases of dengue fever in the geographic area.
- Dengue hemorrhagic fever (plasma leakage) must meet four of the following criteria: 1) fever or history of fever lasting 2–7 days; 2) positive tourniquet test or spontaneous bleeding; 3) platelet count 100x109/L or less; 4) plasma leakage shown either by hemoconcentration with changes in packed-cell volume, or by the development of pleural effusions or ascites.
- Dengue shock syndrome is Dengue hemorrhagic fever with shock. Grade III is narrowing of the pulse pressure or hypotension for age; Grade IV is no detectable pulse or blood pressure.
Treatment
- Intravenous fluids. Crystalloid solutions such as Ringer's lactate may be better than colloid solutions.[8]
- Glucocorticoids are of uncertain benefit.[9]
Causative agent
Dengue fever is caused by infection of one of the four Dengue fever viral serotypes (DEN-1, DEN-2, DEN-3, and DEN-4).[6] The Dengue fever viruses are classified as flaviviruses (family Flaviviridae, genus Dengue).
References
- ↑ World Health Organization. Dengue Fever - Information Sheet. Retrieved on 2007-10-09.
- ↑ 2.0 2.1 2.2 Wilder-Smith A, Schwartz E (2005). "Dengue in travelers". N. Engl. J. Med. 353 (9): 924–32. DOI:10.1056/NEJMra041927. PMID 16135837. Research Blogging.
- ↑ David M. Morens and Anthony S. Fauci, “Dengue and Hemorrhagic Fever: A Potential Threat to Public Health in the United States,” JAMA 299, no. 2 (January 9, 2008), http://jama.ama-assn.org (accessed January 10, 2008).
- ↑ Ramos M, Abell A, Smith B (2006). "Dengue and South Texas: information for clinicians". Texas medicine 102 (8): 56–8. PMID 17115561. [e]
- ↑ 5.0 5.1 Guzmán MG, Kourí G (2002). "Dengue: an update". The Lancet infectious diseases 2 (1): 33–42. PMID 11892494. [e]
- ↑ 6.0 6.1 6.2 Oishi K, Saito M, Mapua CA, Natividad FF (2007). "Dengue illness: clinical features and pathogenesis". J. Infect. Chemother. 13 (3): 125–33. DOI:10.1007/s10156-007-0516-9. PMID 17593497. Research Blogging.
- ↑ Deen JL, Harris E, Wills B, et al (2006). "The WHO dengue classification and case definitions: time for a reassessment". Lancet 368 (9530): 170–3. DOI:10.1016/S0140-6736(06)69006-5. PMID 16829301. Research Blogging.
- ↑ Wills BA, Nguyen MD, Ha TL, et al (2005). "Comparison of three fluid solutions for resuscitation in dengue shock syndrome". N. Engl. J. Med. 353 (9): 877–89. DOI:10.1056/NEJMoa044057. PMID 16135832. Research Blogging.
- ↑ Alejandria M (2005). "Dengue fever". Clinical evidence (13): 887–95. PMID 16135283. [e]