Connective tissue disease: Difference between revisions
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In [[medicine]] and [[rheumatology]], '''connective tissue diseases''' are "a heterogeneous group of disorders, some hereditary, others acquired, characterized by abnormal structure or function of one or more of the elements of connective tissue, i.e., [[collagen]], [[elastin]], or the [[mucopolysaccharide]]s."<ref>{{MeSH}}</ref> | In [[medicine]] and [[rheumatology]], '''connective tissue diseases''' are "a heterogeneous group of disorders, some hereditary, others acquired, characterized by abnormal structure or function of one or more of the elements of connective tissue, i.e., [[collagen]], [[elastin]], or the [[mucopolysaccharide]]s."<ref>{{MeSH}}</ref> | ||
==Classification== | ==Classification== | ||
[[Autoimmune disease]] | [[Autoimmune disease]] | ||
* [[Dermatomyositis]] | * [[Dermatomyositis]] - may have [[autoantibody|autoantibodies]] to [[histidine-tRNA ligase]] (anti-synthetase, [[Jo-1 antibody]]) and to PM-Scl nucleolar antigen complex | ||
* [[Mixed connective tissue disease]] (MCTD). MCTD is an overlap between systemic lupus erythematosus, scleroderma, and polymyositis. Most patients with MCTD have [[autoantibody|autoantibodies]] to [[U1 small nuclear ribonucleoprotein]]s (anti-U1 snRNP OR anti-U1 RNP) | |||
* [[Mixed connective tissue disease]] | |||
* [[Polymyalgia rheumatica]] | * [[Polymyalgia rheumatica]] | ||
* [[Rheumatoid arthritis]] - 80% a positive [[rheumatoid factor]] ([[autoantibody|autoantibodies]] against [[gamma-chain immunoglobulin]]s) | * [[Rheumatoid arthritis]] - 80% a positive [[rheumatoid factor]] ([[autoantibody|autoantibodies]] against [[gamma-chain immunoglobulin]]s) | ||
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| url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=clinical.uthscsa.edu/cite&retmode=ref&cmd=prlinks&id=11014971 }} </ref> | | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=clinical.uthscsa.edu/cite&retmode=ref&cmd=prlinks&id=11014971 }} </ref> | ||
* [[Scleroderma]] - most have [[Antinuclear antibody|antinuclear antibodies]] or [[autoantibody|autoantibodies]] to [[centromere]] or [[DNA topoisomerase I]] (Anti-Scl-70) | * [[Scleroderma]] - most have [[Antinuclear antibody|antinuclear antibodies]] or [[autoantibody|autoantibodies]] to [[centromere]] or [[DNA topoisomerase I]] (Anti-Scl-70) | ||
* [[Systemic lupus erythematosus]] | |||
Cartilage disease | Cartilage disease | ||
* [[Relapsing Polychondritis]] | * [[Relapsing Polychondritis]] | ||
Collagen disease | Collagen disease | ||
* [[Alport Syndrome]] | * [[Alport Syndrome]] | ||
* [[Ehlers-Danlos Syndrome]] | * [[Ehlers-Danlos Syndrome]] | ||
* [[Osteogenesis Imperfecta]] | * [[Osteogenesis Imperfecta]] | ||
==Diagnosis== | |||
===Autoimmune disease=== | |||
Connective tissue disease due to [[autoimmune disease]] may have detectable [[autoantibody|autoantibodies]] to [[autoantigen]]s such as: | |||
* [[Histidine-tRNA ligase]] (anti-synthetase, [[Jo-1 antibody]]) and to PM-Scl nucleolar antigen complex with [[dermatomyositis]]. | |||
* [[U1 small nuclear ribonucleoprotein]]s (anti-U1 snRNP OR anti-U1 RNP) with [[mixed connective tissue disease]]. | |||
* [[Gamma-chain immunoglobulin]]s in [[rheumatoid arthritis]]. | |||
* [[SS-A antigen]] (Anti-Ro antigen) or [[SS-B antigen]] (Anti-La antigen) with [[Sjogren's Syndrome]] | |||
* [[Centromere]] or [[DNA topoisomerase I]] (Anti-Scl-70) with [[scleroderma]] | |||
==References== | ==References== | ||
<references/> | <references/>[[Category:Suggestion Bot Tag]] | ||
Latest revision as of 12:00, 1 August 2024
In medicine and rheumatology, connective tissue diseases are "a heterogeneous group of disorders, some hereditary, others acquired, characterized by abnormal structure or function of one or more of the elements of connective tissue, i.e., collagen, elastin, or the mucopolysaccharides."[1]
Classification
- Dermatomyositis - may have autoantibodies to histidine-tRNA ligase (anti-synthetase, Jo-1 antibody) and to PM-Scl nucleolar antigen complex
- Mixed connective tissue disease (MCTD). MCTD is an overlap between systemic lupus erythematosus, scleroderma, and polymyositis. Most patients with MCTD have autoantibodies to U1 small nuclear ribonucleoproteins (anti-U1 snRNP OR anti-U1 RNP)
- Polymyalgia rheumatica
- Rheumatoid arthritis - 80% a positive rheumatoid factor (autoantibodies against gamma-chain immunoglobulins)
- Sjogren's Syndrome - 60% have autoantibodies to SS-A antigen (Anti-Ro antigen) or SS-B antigen (Anti-La antigen)[2]
- Scleroderma - most have antinuclear antibodies or autoantibodies to centromere or DNA topoisomerase I (Anti-Scl-70)
- Systemic lupus erythematosus
Cartilage disease
Collagen disease
Diagnosis
Autoimmune disease
Connective tissue disease due to autoimmune disease may have detectable autoantibodies to autoantigens such as:
- Histidine-tRNA ligase (anti-synthetase, Jo-1 antibody) and to PM-Scl nucleolar antigen complex with dermatomyositis.
- U1 small nuclear ribonucleoproteins (anti-U1 snRNP OR anti-U1 RNP) with mixed connective tissue disease.
- Gamma-chain immunoglobulins in rheumatoid arthritis.
- SS-A antigen (Anti-Ro antigen) or SS-B antigen (Anti-La antigen) with Sjogren's Syndrome
- Centromere or DNA topoisomerase I (Anti-Scl-70) with scleroderma
References
- ↑ Anonymous (2024), Connective tissue disease (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ Mavragani CP, Tzioufas AG, Moutsopoulos HM (2000). "Sjögren's syndrome: autoantibodies to cellular antigens. Clinical and molecular aspects.". Int Arch Allergy Immunol 123 (1): 46-57. PMID 11014971.