Lipostatic hypothesis

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In 1953, Kennedy proposed what became known as the lipostatic hyothesis. Specifically, he postulated the existence, in the hypothalamus, of a centre that was sensitive to the concentration of metabolites in the circulation, which prevented "an overall surplus of energy intake over expenditure."

References

http://ajpregu.physiology.org/content/286/1/R14.full

http://ajpregu.physiology.org/content/292/1/R37.full