Valacyclovir: Difference between revisions
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imported>Robert Badgett (New page: In pharmacology and virology, '''valacyclovir''' ('''Valtrex''')is "a prodrug of acyclovir; 53% of oral dose excreted as acyclovir in the urine; a 200-400% improvement on acyc...) |
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In [[pharmacology]] and [[virology]], '''valacyclovir''' ('''Valtrex''')is "a prodrug of [[acyclovir]]; 53% of oral dose excreted as acyclovir in the urine; a 200-400% improvement on acyclovir; used in the management of [[Herpes simplex virus|HSV]] and [[Varicella zoster virus|VZV]] infections and the prophylaxis of [[Cytomegalovirus|HCMV]] infections; RN given refers to the monohydrochloride L-valine isomer."<ref>{{MeSH}}</ref> | In [[pharmacology]] and [[virology]], '''valacyclovir''' ('''Valtrex''') is "a prodrug of [[acyclovir]]; 53% of oral dose excreted as acyclovir in the urine; a 200-400% improvement on acyclovir; used in the management of [[Herpes simplex virus|HSV]] and [[Varicella zoster virus|VZV]] infections and the prophylaxis of [[Cytomegalovirus|HCMV]] infections; RN given refers to the monohydrochloride L-valine isomer."<ref>{{MeSH}}</ref> | ||
==History== | |||
Valtrex brand of valacyclovir was approved by the [[Food and Drug Administration]] in the [[United States]] with a [http://www.fda.gov/Drugs/DevelopmentApprovalProcess/HowDrugsareDevelopedandApproved/ApprovalApplications/NewDrugApplicationNDA/ New Drug Application] (NDA) in 1995.<ref>[http://www.accessdata.fda.gov/scripts/cder/drugsatfda/index.cfm?fuseaction=Search.SearchAction&SearchType=BasicSearch&Search_Button=Submit&searchTerm=020487 Drugs@FDA]. U S Food and Drug Administration</ref> A generic version was approved with a [http://www.fda.gov/Drugs/DevelopmentApprovalProcess/HowDrugsareDevelopedandApproved/ApprovalApplications/AbbreviatedNewDrugApplicationANDAGenerics/ Abbreviated New Drug Application] (ANDA) in 2007.<ref>[http://www.accessdata.fda.gov/scripts/cder/drugsatfda/index.cfm?fuseaction=Search.SearchAction&SearchType=BasicSearch&Search_Button=Submit&searchTerm=076588 Drugs@FDA]. U S Food and Drug Administration</ref> | |||
==Pharmacology== | |||
===Administration=== | |||
===Distribution=== | |||
===Metabolism=== | |||
===Excretion=== | |||
===Toxicity=== | |||
[[Drug toxicity]] includes | |||
==External links== | |||
{{CZMed}} | |||
==References== | ==References== | ||
<references/> | <references/> | ||
Revision as of 22:20, 12 July 2010
In pharmacology and virology, valacyclovir (Valtrex) is "a prodrug of acyclovir; 53% of oral dose excreted as acyclovir in the urine; a 200-400% improvement on acyclovir; used in the management of HSV and VZV infections and the prophylaxis of HCMV infections; RN given refers to the monohydrochloride L-valine isomer."[1]
History
Valtrex brand of valacyclovir was approved by the Food and Drug Administration in the United States with a New Drug Application (NDA) in 1995.[2] A generic version was approved with a Abbreviated New Drug Application (ANDA) in 2007.[3]
Pharmacology
Administration
Distribution
Metabolism
Excretion
Toxicity
Drug toxicity includes
External links
The most up-to-date information about Valacyclovir and other drugs can be found at the following sites.
- Valacyclovir - FDA approved drug information (drug label) from DailyMed (U.S. National Library of Medicine).
- Valacyclovir - Drug information for consumers from MedlinePlus (U.S. National Library of Medicine).
- Valacyclovir - Detailed information from DrugBank.
References
- ↑ Anonymous (2024), Valacyclovir (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ Drugs@FDA. U S Food and Drug Administration
- ↑ Drugs@FDA. U S Food and Drug Administration