Glucuronosyltransferase: Difference between revisions
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In [[biochemistry]], '''glucuronosyltransferase''', also called UDP-glucuronosyltransferase, is "a family of enzymes accepting a wide range of substrates, including phenols, alcohols, amines, and fatty acids. They function as drug-metabolizing enzymes that catalyze the conjugation of [[UDPglucuronic acid]] to a variety of endogenous and exogenous compounds."<ref>{{MeSH}}</ref> | In [[biochemistry]], '''glucuronosyltransferase''', also called UDP-glucuronosyltransferase, is "a family of enzymes accepting a wide range of substrates, including phenols, alcohols, amines, and fatty acids. They function as drug-metabolizing enzymes that catalyze the conjugation of [[UDPglucuronic acid]] to a variety of endogenous and exogenous compounds."<ref>{{MeSH}}</ref> | ||
Revision as of 07:30, 9 April 2010
In biochemistry, glucuronosyltransferase, also called UDP-glucuronosyltransferase, is "a family of enzymes accepting a wide range of substrates, including phenols, alcohols, amines, and fatty acids. They function as drug-metabolizing enzymes that catalyze the conjugation of UDPglucuronic acid to a variety of endogenous and exogenous compounds."[1]
Mutation in the UDP-glycuronosyltransferase gene cause Gilbert Syndrome[2] and Crigler-Najjar Syndrome types I[3] and II[4].
Anti-liver kidney microsome Type 3 (LKM3) autoantibodies may be present in chonic hepatitis D,[5] autoimmune hepatitis and chronic active hepatitis.[6]
References
- ↑ Anonymous (2024), Glucuronosyltransferase (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ Online Mendelian Inheritance in Man, OMIM®. Johns Hopkins University, Baltimore, MD. MIM Number: 143500. World Wide Web URL: http://omim.org/.
- ↑ Online Mendelian Inheritance in Man, OMIM®. Johns Hopkins University, Baltimore, MD. MIM Number: 218800. World Wide Web URL: http://omim.org/.
- ↑ Online Mendelian Inheritance in Man, OMIM®. Johns Hopkins University, Baltimore, MD. MIM Number: 606785. World Wide Web URL: http://omim.org/.
- ↑ Obermayer-Straub P, Manns MP (1996). "Cytochromes P450 and UDP-glucuronosyl-transferases as hepatocellular autoantigens.". Baillieres Clin Gastroenterol 10 (3): 501-32. PMID 8905121.
- ↑ Fabien N, Desbos A, Bienvenu J, Magdalou J (2004). "Autoantibodies directed against the UDP-glucuronosyltransferases in human autoimmune hepatitis.". Autoimmun Rev 3 (1): 1-9. DOI:10.1016/S1568-9972(03)00051-X. PMID 14871643. Research Blogging.