Whipple's Disease: Difference between revisions
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imported>Robert Badgett (New page: In medicine, '''Whipple's Disease''' is "a chronic systemic infection by a gram-positive bacterium, Tropheryma whippelii, mainly affecting the small instestine but also the [[joint...) |
imported>Howard C. Berkowitz No edit summary |
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In [[medicine]], '''Whipple's Disease''' is "a chronic systemic infection by a gram-positive bacterium, Tropheryma whippelii, mainly affecting the [[small instestine]] but also the [[joint]]s; [[cardiovascular system]]; and the [[central nervous system]]. The disease is characterized by fat deposits in the [[intestinal mucosa]] and [[lymph node]]s, malabsorption, [[diarrhea]] with fatty stools, [[malnutrition]], and [[arthritis]]."<ref>{{MeSH}}</ref><ref name="pmid17202456">{{cite journal| author=Fenollar F, Puéchal X, Raoult D| title=Whipple's disease. | journal=N Engl J Med | year= 2007 | volume= 356 | issue= 1 | pages= 55-66 | pmid=17202456 | {{subpages}} | ||
In [[medicine]], '''Whipple's Disease''', also called '''hepatolenticular degeneration''', is "a chronic systemic infection by a gram-positive bacterium, Tropheryma whippelii, mainly affecting the [[small instestine]] but also the [[joint]]s; [[cardiovascular system]]; and the [[central nervous system]]. The disease is characterized by fat deposits in the [[intestinal mucosa]] and [[lymph node]]s, malabsorption, [[diarrhea]] with fatty stools, [[malnutrition]], and [[arthritis]]."<ref>{{MeSH}}</ref><ref name="pmid17202456">{{cite journal| author=Fenollar F, Puéchal X, Raoult D| title=Whipple's disease. | journal=N Engl J Med | year= 2007 | volume= 356 | issue= 1 | pages= 55-66 | pmid=17202456 | |||
| url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=clinical.uthscsa.edu/cite&retmode=ref&cmd=prlinks&id=17202456 | doi=10.1056/NEJMra062477 }} </ref> | | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=clinical.uthscsa.edu/cite&retmode=ref&cmd=prlinks&id=17202456 | doi=10.1056/NEJMra062477 }} </ref> | ||
==Diagnosis== | |||
The disease involves abnormalities in metabolism of the trace element, [[copper]]. | |||
While not always present, one sign on physical examination is the [[Kayser-Fleischner ring]], a discoloration of the eye. | |||
==References== | ==References== | ||
<references/> | <references/> | ||
Revision as of 07:58, 13 August 2010
In medicine, Whipple's Disease, also called hepatolenticular degeneration, is "a chronic systemic infection by a gram-positive bacterium, Tropheryma whippelii, mainly affecting the small instestine but also the joints; cardiovascular system; and the central nervous system. The disease is characterized by fat deposits in the intestinal mucosa and lymph nodes, malabsorption, diarrhea with fatty stools, malnutrition, and arthritis."[1][2]
Diagnosis
The disease involves abnormalities in metabolism of the trace element, copper.
While not always present, one sign on physical examination is the Kayser-Fleischner ring, a discoloration of the eye.
References
- ↑ Anonymous (2024), Whipple's Disease (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ Fenollar F, Puéchal X, Raoult D (2007). "Whipple's disease.". N Engl J Med 356 (1): 55-66. DOI:10.1056/NEJMra062477. PMID 17202456. Research Blogging.