Connective tissue disease: Difference between revisions
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imported>Robert Badgett |
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==Classification== | ==Classification== | ||
[[Autoimmune disease]] | [[Autoimmune disease]] | ||
* [[Dermatomyositis]] | * [[Dermatomyositis]] - may have [[autoantibody|autoantibodies]] to [[histidine-tRNA ligase]] (anti-synthetase, [[Jo-1 antibody]]) and to PM-Scl nucleolar antigen complex | ||
* [[Systemic lupus erythematosus]] | * [[Systemic lupus erythematosus]] | ||
* [[Mixed connective tissue disease]] | * [[Mixed connective tissue disease]] (MCTD). MCTD is an overlap between systemic lupus erythematosus, scleroderma, and polymyositis. Most patients with MCTD have [[autoantibody|autoantibodies]] to [[U1 small nuclear ribonucleoprotein]]s (anti-U1 snRNP OR anti-U1 RNP) | ||
* [[Polymyalgia rheumatica]] | * [[Polymyalgia rheumatica]] | ||
* [[Rheumatoid arthritis]] - 80% a positive [[rheumatoid factor]] ([[autoantibody|autoantibodies]] against [[gamma-chain immunoglobulin]]s) | * [[Rheumatoid arthritis]] - 80% a positive [[rheumatoid factor]] ([[autoantibody|autoantibodies]] against [[gamma-chain immunoglobulin]]s) | ||
Revision as of 20:23, 24 March 2010
In medicine and rheumatology, connective tissue diseases are "a heterogeneous group of disorders, some hereditary, others acquired, characterized by abnormal structure or function of one or more of the elements of connective tissue, i.e., collagen, elastin, or the mucopolysaccharides."[1]
Classification
- Dermatomyositis - may have autoantibodies to histidine-tRNA ligase (anti-synthetase, Jo-1 antibody) and to PM-Scl nucleolar antigen complex
- Systemic lupus erythematosus
- Mixed connective tissue disease (MCTD). MCTD is an overlap between systemic lupus erythematosus, scleroderma, and polymyositis. Most patients with MCTD have autoantibodies to U1 small nuclear ribonucleoproteins (anti-U1 snRNP OR anti-U1 RNP)
- Polymyalgia rheumatica
- Rheumatoid arthritis - 80% a positive rheumatoid factor (autoantibodies against gamma-chain immunoglobulins)
- Sjogren's Syndrome - 60% have autoantibodies to SS-A antigen (Anti-Ro antigen) or SS-B antigen (Anti-La antigen)[2]
- Scleroderma - most have antinuclear antibodies or autoantibodies to centromere or DNA topoisomerase I (Anti-Scl-70)
Cartilage disease
Collagen disease
References
- ↑ Anonymous (2024), Connective tissue disease (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ Mavragani CP, Tzioufas AG, Moutsopoulos HM (2000). "Sjögren's syndrome: autoantibodies to cellular antigens. Clinical and molecular aspects.". Int Arch Allergy Immunol 123 (1): 46-57. PMID 11014971.