Autoimmune polyendocrinopathy: Difference between revisions
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imported>Robert Badgett (New page: In medicine, '''autoimmune polyendocrinopathies''', also called '''polyglandular autoimmune syndrome''' or '''autoimmune polyendocrine syndrome''' ('''APS'''), are "autoimmune diseases...) |
imported>Howard C. Berkowitz No edit summary |
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In [[endocrinology]], '''autoimmune polyendocrinopathies''', also called '''polyglandular autoimmune syndrome''' or '''autoimmune polyendocrine syndrome''' ('''APS'''), are "autoimmune diseases affecting multiple endocrine organs.<ref name="MeSH">{{MeSH}}</ref><ref name="pmid15141045">{{cite journal| author=Eisenbarth GS, Gottlieb PA| title=Autoimmune polyendocrine syndromes. | journal=N Engl J Med | year= 2004 | volume= 350 | issue= 20 | pages= 2068-79 | pmid=15141045 | |||
| url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=clinical.uthscsa.edu/cite&email=badgett@uthscdsa.edu&retmode=ref&cmd=prlinks&id=15141045 | doi=10.1056/NEJMra030158 }} <!--Formatted by http://sumsearch.uthscsa.edu/cite/--></ref> | | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=clinical.uthscsa.edu/cite&email=badgett@uthscdsa.edu&retmode=ref&cmd=prlinks&id=15141045 | doi=10.1056/NEJMra030158 }} <!--Formatted by http://sumsearch.uthscsa.edu/cite/--></ref> | ||
==Classification== | ==Classification== | ||
"Type I is characterized by childhood onset and chronic mucocutaneous candidiasis (candidiasis, chronic mucocutaneous)."<ref name="MeSH">{{MeSH}}</ref> | * "Type I is characterized by childhood onset and chronic mucocutaneous candidiasis (candidiasis, chronic mucocutaneous)."<ref name="MeSH">{{MeSH}}</ref> | ||
"Type II exhibits any combination of adrenal insufficiency (addison's disease), lymphocytic thyroiditis (thyroiditis, autoimmune;), hypoparathyroidism; and gonadal failure."<ref name="MeSH">{{MeSH}}</ref> Type II is also called Schmidt's Syndrome. | * "Type II exhibits any combination of adrenal insufficiency (addison's disease), lymphocytic thyroiditis (thyroiditis, autoimmune;), hypoparathyroidism; and gonadal failure."<ref name="MeSH">{{MeSH}}</ref> Type II is also called Schmidt's Syndrome if [[Addison disease]] is present. | ||
IPEX<ref name="pmid19846862">{{cite journal| author=d'Hennezel E, Ben-Shoshan M, Ochs HD, Torgerson TR, Russell LJ, Lejtenyi C et al.| title=FOXP3 forkhead domain mutation and regulatory T cells in the IPEX syndrome. | journal=N Engl J Med | year= 2009 | volume= 361 | issue= 17 | pages= 1710-3 | pmid=19846862 | * IPEX<ref name="pmid19846862">{{cite journal| author=d'Hennezel E, Ben-Shoshan M, Ochs HD, Torgerson TR, Russell LJ, Lejtenyi C et al.| title=FOXP3 forkhead domain mutation and regulatory T cells in the IPEX syndrome. | journal=N Engl J Med | year= 2009 | volume= 361 | issue= 17 | pages= 1710-3 | pmid=19846862 | ||
| url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=clinical.uthscsa.edu/cite&email=badgett@uthscdsa.edu&retmode=ref&cmd=prlinks&id=19846862 | doi=10.1056/NEJMc0907093 }} <!--Formatted by http://sumsearch.uthscsa.edu/cite/--></ref> | | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=clinical.uthscsa.edu/cite&email=badgett@uthscdsa.edu&retmode=ref&cmd=prlinks&id=19846862 | doi=10.1056/NEJMc0907093 }} <!--Formatted by http://sumsearch.uthscsa.edu/cite/--></ref> | ||
Latest revision as of 16:49, 23 August 2010
In endocrinology, autoimmune polyendocrinopathies, also called polyglandular autoimmune syndrome or autoimmune polyendocrine syndrome (APS), are "autoimmune diseases affecting multiple endocrine organs.[1][2]
Classification
- "Type I is characterized by childhood onset and chronic mucocutaneous candidiasis (candidiasis, chronic mucocutaneous)."[1]
- "Type II exhibits any combination of adrenal insufficiency (addison's disease), lymphocytic thyroiditis (thyroiditis, autoimmune;), hypoparathyroidism; and gonadal failure."[1] Type II is also called Schmidt's Syndrome if Addison disease is present.
- IPEX[3]
Etiology/cause
"In both types organ-specific antibodies against a variety of endocrine glands have been detected. The type II syndrome differs from type I in that it is associated with HLA-A1 and B8 haplotypes, onset is usually in adulthood, and candidiasis is not present."[1]
Notable cases
American President John F. Kennedy may have had this syndrome.[4]
References
- ↑ 1.0 1.1 1.2 1.3 Anonymous (2024), Autoimmune polyendocrinopathy (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ Eisenbarth GS, Gottlieb PA (2004). "Autoimmune polyendocrine syndromes.". N Engl J Med 350 (20): 2068-79. DOI:10.1056/NEJMra030158. PMID 15141045. Research Blogging.
- ↑ d'Hennezel E, Ben-Shoshan M, Ochs HD, Torgerson TR, Russell LJ, Lejtenyi C et al. (2009). "FOXP3 forkhead domain mutation and regulatory T cells in the IPEX syndrome.". N Engl J Med 361 (17): 1710-3. DOI:10.1056/NEJMc0907093. PMID 19846862. Research Blogging.
- ↑ Mandel LR (2009). "Endocrine and autoimmune aspects of the health history of John F. Kennedy.". Ann Intern Med 151 (5): 350-4. PMID 19721023.