Carotid intima-media thickness: Difference between revisions
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In [[medicine]] and [[cardiovascular disease]], the '''carotid intima-media thickness''' (CIMT), measuring the [[carotid artery]], is a surrogate outcome measure used in [[randomized controlled trial]]s of the treatment of [[atherosclerosis]].<ref name="pmid18376002">{{cite journal |author=Brown BG, Taylor AJ |title=Does ENHANCE diminish confidence in lowering LDL or in ezetimibe? |journal=N. Engl. J. Med. |volume=358 |issue=14 |pages=1504–7 |year=2008 |month=April |pmid=18376002 |doi=10.1056/NEJMe0801608 |url=http://content.nejm.org/cgi/pmidlookup?view=short&pmid=18376002&promo=ONFLNS19 |issn=}}</ref> It is suggested that "an annual increase of 0.03 mm in intima–media thickness was associated with a tripling of the rate of coronary events."<ref name="pmid18376002"/> | In [[medicine]] and [[cardiovascular disease]], the '''carotid intima-media thickness''' (CIMT), measuring the [[carotid artery]], is a surrogate outcome measure used in [[randomized controlled trial]]s of the treatment of [[atherosclerosis]].<ref name="pmid18376002">{{cite journal |author=Brown BG, Taylor AJ |title=Does ENHANCE diminish confidence in lowering LDL or in ezetimibe? |journal=N. Engl. J. Med. |volume=358 |issue=14 |pages=1504–7 |year=2008 |month=April |pmid=18376002 |doi=10.1056/NEJMe0801608 |url=http://content.nejm.org/cgi/pmidlookup?view=short&pmid=18376002&promo=ONFLNS19 |issn=}}</ref> It is suggested that "an annual increase of 0.03 mm in intima–media thickness was associated with a tripling of the rate of coronary events."<ref name="pmid18376002"/> | ||
A [[meta-analysis]] concludes "the modest relation between CIMT and coronary atherosclerosis most likely reflects variability in atherosclerosis development between the vascular beds rather than limitations of CIMT measurements."<ref name="pmid17277033">{{cite journal |author=Bots ML, Baldassarre D, Simon A, ''et al'' |title=Carotid intima-media thickness and coronary atherosclerosis: weak or strong relations? |journal=Eur. Heart J. |volume=28 |issue=4 |pages=398–406 |year=2007 |month=February |pmid=17277033 |doi=10.1093/eurheartj/ehl482 |url=http://eurheartj.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=17277033 |issn=}}</ref> | The relationship between changes in carotid intima-media thickness and cardiac events is not clear.<ref name="pmid22541275">{{cite journal| author=Lorenz MW, Polak JF, Kavousi M, Mathiesen EB, Völzke H, Tuomainen TP et al.| title=Carotid intima-media thickness progression to predict cardiovascular events in the general population (the PROG-IMT collaborative project): a meta-analysis of individual participant data. | journal=Lancet | year= 2012 | volume= 379 | issue= 9831 | pages= 2053-62 | pmid=22541275 | doi=10.1016/S0140-6736(12)60441-3 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22541275 }} </ref> A [[meta-analysis]] concludes "the modest relation between CIMT and coronary atherosclerosis most likely reflects variability in atherosclerosis development between the vascular beds rather than limitations of CIMT measurements."<ref name="pmid17277033">{{cite journal |author=Bots ML, Baldassarre D, Simon A, ''et al'' |title=Carotid intima-media thickness and coronary atherosclerosis: weak or strong relations? |journal=Eur. Heart J. |volume=28 |issue=4 |pages=398–406 |year=2007 |month=February |pmid=17277033 |doi=10.1093/eurheartj/ehl482 |url=http://eurheartj.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=17277033 |issn=}}</ref> | ||
==References== | ==References== | ||
<references/> | <references/> | ||
Revision as of 12:28, 12 June 2012
In medicine and cardiovascular disease, the carotid intima-media thickness (CIMT), measuring the carotid artery, is a surrogate outcome measure used in randomized controlled trials of the treatment of atherosclerosis.[1] It is suggested that "an annual increase of 0.03 mm in intima–media thickness was associated with a tripling of the rate of coronary events."[1]
The relationship between changes in carotid intima-media thickness and cardiac events is not clear.[2] A meta-analysis concludes "the modest relation between CIMT and coronary atherosclerosis most likely reflects variability in atherosclerosis development between the vascular beds rather than limitations of CIMT measurements."[3]
References
- ↑ 1.0 1.1 Brown BG, Taylor AJ (April 2008). "Does ENHANCE diminish confidence in lowering LDL or in ezetimibe?". N. Engl. J. Med. 358 (14): 1504–7. DOI:10.1056/NEJMe0801608. PMID 18376002. Research Blogging.
- ↑ Lorenz MW, Polak JF, Kavousi M, Mathiesen EB, Völzke H, Tuomainen TP et al. (2012). "Carotid intima-media thickness progression to predict cardiovascular events in the general population (the PROG-IMT collaborative project): a meta-analysis of individual participant data.". Lancet 379 (9831): 2053-62. DOI:10.1016/S0140-6736(12)60441-3. PMID 22541275. Research Blogging.
- ↑ Bots ML, Baldassarre D, Simon A, et al (February 2007). "Carotid intima-media thickness and coronary atherosclerosis: weak or strong relations?". Eur. Heart J. 28 (4): 398–406. DOI:10.1093/eurheartj/ehl482. PMID 17277033. Research Blogging.