Cefadroxil: Difference between revisions

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'''Cefadroxil''' is a first-generation [[cephalosporin]] antibiotic, is used to treat urinary tract infections, skin  infections, pharyngitis, and tonsillitis.  The compound is active against bacteria due to the [[beta-lactam]] moiety and thus is similar to [[penicillin]]. Cefadroxil can be used to treat infections of [[S. pneumoniae]], [[H. influenzae]], [[staphylococci]], [[S. pyogenes]], [[E. coli]], [[P. mirabilis]], [[Klebsiella sp]], coagulase-negative staphylococci and Streptococcus pyogenes.
'''Cefadroxil''' is a first-generation [[cephalosporin]] antibiotic, is used to treat urinary tract infections, skin  infections, pharyngitis, and tonsillitis.  The compound is active against bacteria due to the [[beta-lactam]] moiety and thus is similar to [[penicillin]]. Cefadroxil can be used to treat infections of [[S. pneumoniae]], [[H. influenzae]], [[staphylococci]], [[S. pyogenes]], [[E. coli]], [[P. mirabilis]], [[Klebsiella sp]], coagulase-negative staphylococci and Streptococcus pyogenes.
== Mechanism of action ==
Like all beta-lactam antibiotics, cefadroxil binds to specific penicillin-binding proteins located inside the bacterial cell wall, disrupting the last stage of bacterial cell wall synthesis. Due to the defective bacterial cell walls, cell lysis is induced by the autolytic enzymes [[autolysin]]s. Cefadroxil may interfere with an autolysin inhibitor.
== Chemistry ==
The IUPAC chemical name for cefacroxil is 7-[[2-amino-2-(4-hydroxyphenyl)acetyl]amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid and it has chemical formula C<sub>16</sub>H<sub>17</sub>N<sub>3</sub>O<sub>5</sub>S, giving it a molecular mass of 363.3883 g/mol.  The compound is active against bacteria due to the presence of the [[beta-lactam]] moiety.  Like other cephalosporins, it is similar to [[penicillin]] but contains a six-membered ring rather than the five-membered ring present in penicillins.
== Synonyms and brand names ==
* '''Synonyms'''
* Cefadroxil Monohydrate
* Cefradroxil
* CDX
* '''Brand names'''
*Baxan®
*Bidocef®
*Cefa-Drops®
*Cefamox®
*Cephos®
*Duracef®
*Kefroxil®
*Oracefal®
*Sedral®
*Sumacef®
*Ultracef®
== External links ==
{{CZMed}}

Revision as of 16:28, 5 April 2009

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(CC) Image: David E. Volk
cefadroxil
IUPAC name: see chemistry section
Synonyms: cefradroxil
Formula: C16H17N3O5S
 Uses: antibiotic drug
 Properties: beta-lactam
 Hazards: see drug interactions
Mass (g/mol): CAS #:
363.3883 66592-87-8


Cefadroxil is a first-generation cephalosporin antibiotic, is used to treat urinary tract infections, skin infections, pharyngitis, and tonsillitis. The compound is active against bacteria due to the beta-lactam moiety and thus is similar to penicillin. Cefadroxil can be used to treat infections of S. pneumoniae, H. influenzae, staphylococci, S. pyogenes, E. coli, P. mirabilis, Klebsiella sp, coagulase-negative staphylococci and Streptococcus pyogenes.

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