Tenofovir: Difference between revisions

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imported>David E. Volk
imported>David E. Volk
(chem infobox)
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[[Image:Tenofovir structure.jpg|right|thumb|200px|{{#ifexist:Template:Tenofovir structure.jpg/credit|{{Tenofovir structure.jpg/credit}}<br/>|}}Tenofovir]]
 
{{Chem infobox
|align=right
|image=[[Image:Tenofovir structure.jpg|center|thumb|200px]]
|width=200px
|molname=tenofovir
|synonyms=  TDF, PMPA
|molformula= C<sub>9</sub>H<sub>14</sub>N<sub>5</sub>O<sub>4</sub>P
|molmass= 287.2123
|uses=HIV/AIDS & Hep. B
|properties=RT inhibitor, adenosine analog
|hazards=see drug interactions
|iupac= see chemistry section
|casnumber=147127-20-6
}}
 
'''Tenofovir''' is a nucleotide analog [[reverse transcritase inhibitor]] (nRTI) [[antiviral drug]] used to treat [[HIV]]/[[AIDS]] and is in clinical trials for treatment of [[hepatitis B]] infection.  The triphosphate from of the drug competes with the natural [[DNA]] [[nucleotide]] [[deoxyadenosine triphosphate]] (dATP) during DNA formation and it acts as a DNA chain terminator once incorporated because it lacks the normal [[deoxyribose]] sugar needed for connecting to the next DNA base.  
'''Tenofovir''' is a nucleotide analog [[reverse transcritase inhibitor]] (nRTI) [[antiviral drug]] used to treat [[HIV]]/[[AIDS]] and is in clinical trials for treatment of [[hepatitis B]] infection.  The triphosphate from of the drug competes with the natural [[DNA]] [[nucleotide]] [[deoxyadenosine triphosphate]] (dATP) during DNA formation and it acts as a DNA chain terminator once incorporated because it lacks the normal [[deoxyribose]] sugar needed for connecting to the next DNA base.  
== Chemistry ==
The IUPAC chemical name for tenofovir is [(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethylphosphonic acid and it has chemical formula C<sub>9</sub>H<sub>14</sub>N<sub>5</sub>O<sub>4</sub>P, giving it a molecular mass of 287.2123 g/mol.  It is chemically similar to the natural neucleotide adenosine but lacks a ribose sugar unit.


== Synonyms and brand names ==
== Synonyms and brand names ==

Revision as of 13:58, 24 March 2008

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Tenofovir structure.jpg
tenofovir
IUPAC name: see chemistry section
Synonyms: TDF, PMPA
Formula: C9H14N5O4P
 Uses: HIV/AIDS & Hep. B
 Properties: RT inhibitor, adenosine analog
 Hazards: see drug interactions
Mass (g/mol): CAS #:
287.2123 147127-20-6


Tenofovir is a nucleotide analog reverse transcritase inhibitor (nRTI) antiviral drug used to treat HIV/AIDS and is in clinical trials for treatment of hepatitis B infection. The triphosphate from of the drug competes with the natural DNA nucleotide deoxyadenosine triphosphate (dATP) during DNA formation and it acts as a DNA chain terminator once incorporated because it lacks the normal deoxyribose sugar needed for connecting to the next DNA base.

Chemistry

The IUPAC chemical name for tenofovir is [(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethylphosphonic acid and it has chemical formula C9H14N5O4P, giving it a molecular mass of 287.2123 g/mol. It is chemically similar to the natural neucleotide adenosine but lacks a ribose sugar unit.

Synonyms and brand names

Synonyms

  • Tenofovir disoproxil
  • Tenofovir disoproxil fumarate
  • D,L-Tenofovir
  • TDF
  • PMPA

Brand Names

  • Apropovir
  • Viread

External links

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