Protease inhibitor: Difference between revisions
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A '''protease inhibitor''' is chemical compound that inhibits the so for the treatment of [[HIV]]/[[AIDS]], but also for the treatment of other viruses, such as chicken pox. All cells have protease enzymes that cleavie cellular proteins, which is required for normal cell live cycles. By distrupting the use of natural proteases within the cell, the use of protease inhibitors causes severe side effects, and because the half-life of many protease inhibitors is short (3-5 hr.) the drugs must given every 4-6 hours. Protease inhibitors are often structural mimics of the proteins active (binding) sites on which the proteases would normally bind. | A '''protease inhibitor''' is a chemical compound that inhibits the functions of proteases to control viral infections, especially so for the treatment of [[HIV]]/[[AIDS]], but also for the treatment of other viruses, such as chicken pox. All cells have protease enzymes that cleavie cellular proteins, which is required for normal cell live cycles. By distrupting the use of natural proteases within the cell, the use of protease inhibitors causes severe side effects, and because the half-life of many protease inhibitors is short (3-5 hr.) the drugs must given every 4-6 hours. Protease inhibitors are often structural mimics of the proteins active (binding) sites on which the proteases would normally bind. | ||
Revision as of 10:46, 29 January 2008
A protease inhibitor is a chemical compound that inhibits the functions of proteases to control viral infections, especially so for the treatment of HIV/AIDS, but also for the treatment of other viruses, such as chicken pox. All cells have protease enzymes that cleavie cellular proteins, which is required for normal cell live cycles. By distrupting the use of natural proteases within the cell, the use of protease inhibitors causes severe side effects, and because the half-life of many protease inhibitors is short (3-5 hr.) the drugs must given every 4-6 hours. Protease inhibitors are often structural mimics of the proteins active (binding) sites on which the proteases would normally bind.
protease inhibitors used to treat HIV/AIDS