Thrombocytopenia: Difference between revisions
Jump to navigation
Jump to search
imported>Robert Badgett |
imported>Robert Badgett |
||
| Line 21: | Line 21: | ||
A [[systematic review]] has identified common causes of drug-induced thrombocytopenia.<ref name="pmid9867731">{{cite journal |author=George JN, Raskob GE, Shah SR, ''et al'' |title=Drug-induced thrombocytopenia: a systematic review of published case reports |journal=Ann. Intern. Med. |volume=129 |issue=11 |pages=886–90 |year=1998 |pmid=9867731 |doi=|url=http://www.annals.org/cgi/content/full/129/11_Part_1/886}}</ref> | A [[systematic review]] has identified common causes of drug-induced thrombocytopenia.<ref name="pmid9867731">{{cite journal |author=George JN, Raskob GE, Shah SR, ''et al'' |title=Drug-induced thrombocytopenia: a systematic review of published case reports |journal=Ann. Intern. Med. |volume=129 |issue=11 |pages=886–90 |year=1998 |pmid=9867731 |doi=|url=http://www.annals.org/cgi/content/full/129/11_Part_1/886}}</ref> | ||
Drug-induced thrombocytopenia maybe immune | Drug-induced thrombocytopenia maybe immune mediated by antibodies against immune complexes of drugs bound to [[Platelet glycoprotein GPIIb-IIIa complex]] or Ib/V/IX complexes.<ref name="pmid17687133">{{cite journal |author=Aster RH, Bougie DW |title=Drug-induced immune thrombocytopenia |journal=N. Engl. J. Med. |volume=357 |issue=6 |pages=580–7 |year=2007 |pmid=17687133 |doi=10.1056/NEJMra066469|url=http://content.nejm.org/cgi/content/full/357/6/580}}</ref> [[Heparin-induced thrombocytopenia]] (HIT) is usually caused by antibodies against immune complexes of platelet factor 4 (PF4) and [[heparin]].<ref name="pmid16928996">{{cite journal |author=Arepally GM, Ortel TL |title=Clinical practice. Heparin-induced thrombocytopenia |journal=N. Engl. J. Med. |volume=355 |issue=8 |pages=809–17 |year=2006 |pmid=16928996 |doi=10.1056/NEJMcp052967|url=http://content.nejm.org/cgi/content/full/355/8/809}}</ref> Other drugs include [[vancomycin]] | ||
<ref name="pmid17329697">{{cite journal |author=Von Drygalski A, Curtis BR, Bougie DW, ''et al'' |title=Vancomycin-induced immune thrombocytopenia |journal=N. Engl. J. Med. |volume=356 |issue=9 |pages=904–10 |year=2007 |pmid=17329697 |doi=10.1056/NEJMoa065066}}</ref> and oxaliplatin<ref name="pmid12859182">{{cite journal |author=Dold FG, Mitchell EP |title=Sudden-onset thrombocytopenia with oxaliplatin |journal=Ann. Intern. Med. |volume=139 |issue=2 |pages=E156 |year=2003 |pmid=12859182 |doi=|url=http://www.annals.org/cgi/content/full/139/2/W-59}}</ref> | <ref name="pmid17329697">{{cite journal |author=Von Drygalski A, Curtis BR, Bougie DW, ''et al'' |title=Vancomycin-induced immune thrombocytopenia |journal=N. Engl. J. Med. |volume=356 |issue=9 |pages=904–10 |year=2007 |pmid=17329697 |doi=10.1056/NEJMoa065066}}</ref> and oxaliplatin<ref name="pmid12859182">{{cite journal |author=Dold FG, Mitchell EP |title=Sudden-onset thrombocytopenia with oxaliplatin |journal=Ann. Intern. Med. |volume=139 |issue=2 |pages=E156 |year=2003 |pmid=12859182 |doi=|url=http://www.annals.org/cgi/content/full/139/2/W-59}}</ref> | ||
Revision as of 10:54, 11 January 2008
Thrombocytopenia is a decrease in the platelet count. The half-life of a platelet in a normal person is about 4 days.[1]
Classification
The following classification is proposed by Robbins and Cotran.[2]
Decreased production of platelets
Decreased survival of platelets
Immunolologic destruction
Autoimmune includes immune thrombocytopenia purpura or Werlhof's Disease. The chronic form in adults is usually caused by antibodies to Platelet glycoprotein GPIIb-IIIa complex or Ib-IX.[2]
- Isoimmune
- Drug associated
- Infections
Nonimmunolologic destruction
- Disseminated intravascular coagulation (DIC)
- Giant hemangiomas
Microangiopathic hemolytic anemias (MAHAs) include thrombotic thrombocytopenia purpura (TTP) and hemolytic uremia syndrome (HUS). TTP is usually an inherited or acquired deficiency of von Willebrand factor (vWF) metalloprotease, also called ADAMTS 13.
Cause/etiology
Medications
A systematic review has identified common causes of drug-induced thrombocytopenia.[3]
Drug-induced thrombocytopenia maybe immune mediated by antibodies against immune complexes of drugs bound to Platelet glycoprotein GPIIb-IIIa complex or Ib/V/IX complexes.[4] Heparin-induced thrombocytopenia (HIT) is usually caused by antibodies against immune complexes of platelet factor 4 (PF4) and heparin.[5] Other drugs include vancomycin [6] and oxaliplatin[7]
References
- ↑ Fritz E, Ludwig H, Scheithauer W, Sinzinger H (1986). "Shortened platelet half-life in multiple myeloma". Blood 68 (2): 514–20. PMID 3730614. [e]
- ↑ 2.0 2.1 Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. (2005). Robbins and Cotran pathologic basis of disease. St. Louis, Mo: Elsevier Saunders. ISBN 0-7216-0187-1.
- ↑ George JN, Raskob GE, Shah SR, et al (1998). "Drug-induced thrombocytopenia: a systematic review of published case reports". Ann. Intern. Med. 129 (11): 886–90. PMID 9867731. [e]
- ↑ Aster RH, Bougie DW (2007). "Drug-induced immune thrombocytopenia". N. Engl. J. Med. 357 (6): 580–7. DOI:10.1056/NEJMra066469. PMID 17687133. Research Blogging.
- ↑ Arepally GM, Ortel TL (2006). "Clinical practice. Heparin-induced thrombocytopenia". N. Engl. J. Med. 355 (8): 809–17. DOI:10.1056/NEJMcp052967. PMID 16928996. Research Blogging.
- ↑ Von Drygalski A, Curtis BR, Bougie DW, et al (2007). "Vancomycin-induced immune thrombocytopenia". N. Engl. J. Med. 356 (9): 904–10. DOI:10.1056/NEJMoa065066. PMID 17329697. Research Blogging.
- ↑ Dold FG, Mitchell EP (2003). "Sudden-onset thrombocytopenia with oxaliplatin". Ann. Intern. Med. 139 (2): E156. PMID 12859182. [e]
External links
- University of Oklahoma Health Sciences Center's Platelets on the Web. This includes a database of reports of drug-induced thrombocytopenia.