Thrombocytopenia: Difference between revisions
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'''Thrombocytopenia''' is a decrease in the platelet count. The half-life of a platelet in a normal person is about 4 days.<ref name="pmid3730614">{{cite journal |author=Fritz E, Ludwig H, Scheithauer W, Sinzinger H |title=Shortened platelet half-life in multiple myeloma |journal=Blood |volume=68 |issue=2 |pages=514–20 |year=1986 |pmid=3730614 |doi=}}</ref> | '''Thrombocytopenia''' is a decrease in the platelet count. The half-life of a platelet in a normal person is about 4 days.<ref name="pmid3730614">{{cite journal |author=Fritz E, Ludwig H, Scheithauer W, Sinzinger H |title=Shortened platelet half-life in multiple myeloma |journal=Blood |volume=68 |issue=2 |pages=514–20 |year=1986 |pmid=3730614 |doi=}}</ref> | ||
== | ==Cause/etiology== | ||
===Medications=== | ===Medications=== | ||
A [[systematic review]] has identified common causes of drug-induced thrombocytopenia.<ref name="pmid9867731">{{cite journal |author=George JN, Raskob GE, Shah SR, ''et al'' |title=Drug-induced thrombocytopenia: a systematic review of published case reports |journal=Ann. Intern. Med. |volume=129 |issue=11 |pages=886–90 |year=1998 |pmid=9867731 |doi=|url=http://www.annals.org/cgi/content/full/129/11_Part_1/886}}</ref> | A [[systematic review]] has identified common causes of drug-induced thrombocytopenia.<ref name="pmid9867731">{{cite journal |author=George JN, Raskob GE, Shah SR, ''et al'' |title=Drug-induced thrombocytopenia: a systematic review of published case reports |journal=Ann. Intern. Med. |volume=129 |issue=11 |pages=886–90 |year=1998 |pmid=9867731 |doi=|url=http://www.annals.org/cgi/content/full/129/11_Part_1/886}}</ref> | ||
Revision as of 14:15, 6 January 2008
Thrombocytopenia is a decrease in the platelet count. The half-life of a platelet in a normal person is about 4 days.[1]
Cause/etiology
Medications
A systematic review has identified common causes of drug-induced thrombocytopenia.[2]
Drug-induced thrombocytopenia maybe immune medicated.[3] Heparin-induced thrombocytopenia (HIT) is caused by anti-platelet antibodies.[4] Other drugs include vancomycin [5] and oxaliplatin[6]
References
- ↑ Fritz E, Ludwig H, Scheithauer W, Sinzinger H (1986). "Shortened platelet half-life in multiple myeloma". Blood 68 (2): 514–20. PMID 3730614. [e]
- ↑ George JN, Raskob GE, Shah SR, et al (1998). "Drug-induced thrombocytopenia: a systematic review of published case reports". Ann. Intern. Med. 129 (11): 886–90. PMID 9867731. [e]
- ↑ Aster RH, Bougie DW (2007). "Drug-induced immune thrombocytopenia". N. Engl. J. Med. 357 (6): 580–7. DOI:10.1056/NEJMra066469. PMID 17687133. Research Blogging.
- ↑ Arepally GM, Ortel TL (2006). "Clinical practice. Heparin-induced thrombocytopenia". N. Engl. J. Med. 355 (8): 809–17. DOI:10.1056/NEJMcp052967. PMID 16928996. Research Blogging.
- ↑ Von Drygalski A, Curtis BR, Bougie DW, et al (2007). "Vancomycin-induced immune thrombocytopenia". N. Engl. J. Med. 356 (9): 904–10. DOI:10.1056/NEJMoa065066. PMID 17329697. Research Blogging.
- ↑ Dold FG, Mitchell EP (2003). "Sudden-onset thrombocytopenia with oxaliplatin". Ann. Intern. Med. 139 (2): E156. PMID 12859182. [e]