Central dogma of molecular genetics: Difference between revisions

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<blockquote>"My mind was, that a dogma was an idea for which there was no resonable evidence"  
<blockquote>"My mind was, that a dogma was an idea for which there was no resonable evidence"  
<ref>See discussion in Chapter 7.  Horace Freeland Judson (1979). The Eight Day of Creation: Makers of the Revolution in Molecular Biology. ISBN 0140178007.</ref> ([[Francis Crick]])</blockquote>
<ref>See discussion in Chapter 7.  Horace Freeland Judson (1979). ''The Eight Day of Creation: Makers of the Revolution in Molecular Biology.'' ISBN 0140178007.</ref> ([[Francis Crick]])</blockquote>


Famously, Crick seems to have misunderstood the precise meaning of the word ''dogma'' whem formulating his brilliant hypothesis of how the [[genetic code]] of [[genes]] is used in cells during synthesis of proteins to determine, via RNA intermediates, the order of amino acid residues in proteins.
Famously, Crick seems to have misunderstood the precise meaning of the word ''dogma'' when formulating his brilliant hypothesis of how the [[genetic code]] of [[genes]] is used in cells during synthesis of proteins to determine, via RNA intermediates, the order of amino acid residues in proteins.


The core of his idea seems to have fallen into place in February 1956 with the idea of adapter  molecules (now called t-RNA) , whicn align particular amino acids against a genetically coded message, and developed into the concept he dubbed The Central Dogma in September 1957.
The core of his idea seems to have fallen into place in February 1956 with the idea of ''adapter  molecules'' (now called [[tRNA]]) , which align particular amino acids against a genetically coded message, and developed by Crick into the concept he dubbed ''The Central Dogma'' in September 1957.


As reported in the by Horace Judson, in 1957 Crick wrote "On protein synthesis" <ref>Crick FH (1958) On protein synthesis Symp Soc Exp Biol. 12:138-63</ref>:
As reported in the by Horace Judson, in 1957 Crick wrote ''On protein synthesis'' <ref>Crick FH (1958) On protein synthesis Symp Soc Exp Biol. 12:138-63</ref>:


<blockquote>'''The Central Dogma''. This states that once "information" has passed into protein ''it cannot get out again''. In more detail, the transfer of information from nucleic acid to nucleic acid , or from nucleic acid tio protein may be possible, but transfer from protein to protein, or from protein to nucleic acid is impossible. Information means here the ''precise'' determination of sequence, either of bases in the nucleic acid or of amino acid residues in the protein.</blockquote>
<blockquote>'''The Central Dogma''. This states that once "information" has passed into protein ''it cannot get out again''. In more detail, the transfer of information from nucleic acid to nucleic acid , or from nucleic acid tio protein may be possible, but transfer from protein to protein, or from protein to nucleic acid is impossible. Information means here the ''precise'' determination of sequence, either of bases in the nucleic acid or of amino acid residues in the protein.</blockquote>

Revision as of 06:34, 28 January 2007

The central dogma of molecular biology refers to the concept put forward by Francis Crick that information flow in the cell goes from the deoxynucleic acid DNA, to the ribonucleic acid messenger RNA, to protein, but never from protein to nucleic acids. By information, is meant the precise order of monomers in a biological polymer (such as DNA or protein).


"My mind was, that a dogma was an idea for which there was no resonable evidence" [1] (Francis Crick)

Famously, Crick seems to have misunderstood the precise meaning of the word dogma when formulating his brilliant hypothesis of how the genetic code of genes is used in cells during synthesis of proteins to determine, via RNA intermediates, the order of amino acid residues in proteins.

The core of his idea seems to have fallen into place in February 1956 with the idea of adapter molecules (now called tRNA) , which align particular amino acids against a genetically coded message, and developed by Crick into the concept he dubbed The Central Dogma in September 1957.

As reported in the by Horace Judson, in 1957 Crick wrote On protein synthesis [2]:

'The Central Dogma. This states that once "information" has passed into protein it cannot get out again. In more detail, the transfer of information from nucleic acid to nucleic acid , or from nucleic acid tio protein may be possible, but transfer from protein to protein, or from protein to nucleic acid is impossible. Information means here the precise determination of sequence, either of bases in the nucleic acid or of amino acid residues in the protein.


References

  1. ↑ See discussion in Chapter 7. Horace Freeland Judson (1979). The Eight Day of Creation: Makers of the Revolution in Molecular Biology. ISBN 0140178007.
  2. ↑ Crick FH (1958) On protein synthesis Symp Soc Exp Biol. 12:138-63
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